Question

Can triglyceride hydrolysis feed gluconeogenesis? Explain your answer.

BIOCHEMISTRY

Answer 1

Yes , Triglyceride hydrolysis feed Gluconeogenesis .

Triglyceride/triglycerol is formed as chylomicrons and enters into the blood stream through thoracic duct of stomach where triglycerides concerted into the 1,2 diacylglycerols +free fatty acids (FFA) by enzyme gastric lipase . Next these enters into small intestine by pancreatic lipase enzyme 1,2 diacylglycerols and fatty acids converts into 2 monoacylglycerols +FFA . These undergoes Hydrolysis reaction and converts into free fatty acids and glycerol.

Above process is known as Lipolysis .

When glucose levels are down /decreased / low .Triglycerides converts into the Acetyl coA which is main responsible for generation of ATP by areobic process i.e Gluconeogenesis .

The final product/phase of the Gluconeogenesis is Glucose .

Glucose generates energy in the form of ATP .

For detail understanding provided the cycle of Gluconeogenesis

Gluconeogenesis : Acetyl coA converts into pyruvate and then into phenol pyruvate , fructose -6 . From fructose -6 , Glucose 6 is generated and it is finally converted into Glucose.

By this way triglyceride hydrolysis feed Gluconeogenesis .