Fructose 2,6-bisphosphate
a. activates fructose 1,6-bisphosphatase.
b. inhibits fructose 2,6-bisphosphatase.
c. activates pyruvate kinase.
d. activates phosphofructokinase.
e. production is stimulated by glucagon.
Fructose 2,6-bisphosphate a. activates fructose 1,6-bisphosphatase. b. inhibits fructose 2,6-bisphosphatase. c. activates pyruvate kinase. d. activates...
BIOCHEM Compare and contrast how fructose‐1,6‐bisphosphatase and phosphofructokinase are regulated in response to energy charge. What specific allosteric effectors are involved? What is meant by reciprocal regulation. Pyruvate kinase is also regulated allosterically by fructose‐1,6‐bisphosphate. Explain the rationale for this regulation. Do these compounds stimulate or inhibit pyruvate kinase?
Conversely, in muscle cells, low energy charge ["activates or inhibits"] glycolysis. Specifically, AMP activates the enzyme ["phosphofructokinase 1 or hexokinase"] . Pyruvate kinase is positively regulated by [fructose 1,6-bisphosphate or glucose 6-phosphate"] through feed-forward activation. The enzyme ["hexokinase or phosphofructokinase 1] is not affected. Choose one of the answers in the brackets.
PART A OPTIONS FOR BLANKS: 1- inhibits, does not affect, stimulates 2- fructose-1,6-biphosphatase-1, pyruvate kinase, phosphofructokinase-1 3- phosphofructokinase-1, fructose-1,6-biphosphatase-1, phosphoenolpyruvate carboxylate PART B OPTIONS FOR BLANK: Activity Curve A, Neither, Activity Curve B Part 1 (3 points) See Hint High levels of fructose-2,6-BP reciprocally regulate glycolysis and gluconeogenesis. Fructose-2,6-BP flux through the glycolytic pathway by increasing the activity of Flux through the gluconeogenic pathway is inhibited by fructose-2,6- BP, which decreases the activity of Part 2 (1 point) See Hint...
When the blood glucose concentration is low, the pancreas secretes glucagon to signal the liver to produce glucose and glucose-1-phosphate. Which metabolic steps are involved in this biosignaling pathway? Inactivation of glycogen synthase via phosphorylation by protein kinase A Activation of glycogen synthase via phosphorylation by protein kinase A Activation of phosphofructokinase-2 via phosphorylation by protein kinase A Activation of fructose-2,6-bisphosphatase via phosphorylation by protein kinase A Activation of phosphofructokinase-1 by fructose-2,6-bisphosphate Inhibition of fructose-1,6-bisphosphatase by fructose-2,6-bisphosphate Inactivation of pyruvate...
After eating, elevated levels of fructose 6-phosphate will stimulate ["phosphoprotein phosphatase or Protein kinase A (PKA)"]. This causes the dephosphorylation of the the phosphofructokinase 2/fructose 2,6-bisphosphate polypeptide to stimulate the activity of ["phosphofructokinase 2 or fructose 2,6-bisphosphatase"].This results in an increase of ["fructose 6-phosphate or fructose 2,6-bisphosphate"] and activation of ["glycolysis or gluconeogenesis"] . Choose one of the answers in the brackets.
Explain in detail how PFK-1, hexokinase, glucokinase, pyruvate kinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase-1, pyruvate carboxylase & PEPCK are regulated & compare their regulation in liver vs. skeletal muscle & brain when blood glucose levels are high (i.e. a fed state) & low (i.e. a fasting or starvation state).
In anaerobic metabolism, what is the fate of pyruvate produced by glycolysis a. 2 b. 4 c. 6 d. 8 e. none of the above Fructose 1,6-bisphosphate is: a. stimulated by fructose-2,6-bisphosphate b. stimulated by citrate c. stimulated by AMP d. not subject to allosteric control e. none of the above
D) Now let's think about the role of fructose 2,6-bisphosphate and the role of glucagon in stimulating liver cells to make and secrete glucose to the blood. in the level of fructose 2,6-bisphosphate. High glucagon would cause a(an) (Write either “increase” or “decrease” in that blank.) What enzyme does fructose 2,6-bisphosphate ACTIVATE? E) OK, let's go back to the first of those glycolysis steps that you said was highly regulated. Using THERMODYNAMICS terms, what is it about this reaction that...
Which pair of opposite enzymes in the glycolysis and gluconeogenesis pathway are not allosterically regulated but rather regulated by compartmentalization? Select one: a. pyruvate kinase/PEP carboxykinase b. phosphofructokinase 1/fructose-1,6-bisphosphatase c. phosphofructokinase 2/fructose-2,6-bisphosphatase d. hexokinase/glucose-6-phosphatase
match the following 1. Fructose 1,6-bisphosphate is converted to Fructose 6- phosphate through this enzyme _____ 2. Synthesis of glucose from noncarbohydrate precursors _____ 3. Stage in which two molecules of ATP are consumed _____ 4. This is formed from pyruvate in yeast and several other microorganisms through fermentation _____ 5. The isomerization of glucose 6-phosphate to fructose 6-phosphate is a coversion of an aldose into a …._____ 6. Pyruvate is converted by pyruvate carboxylase into this intermediate _____ 7....