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1. Which of the following mutations is the most likely to be neutral? A) A nonsense...
Which of the following mutations would be most likely to have a harmful effect on an organism? (A) a deletion of three nucleotides near the middle of a gene (B) a single nucleotide deletion in the middle of an intron (C) a single nucleotide deletion near the end of the coding sequence (D) a single nucleotide insertion downstream of, and close to, the start of the coding sequence In this problem, why (c) cannot be the answer?? Single nucleotide deletion...
5. A eukaryotic protein-encoding gene contains two introns and three exons: exon 1–intron 1–exon 2–intron 2–exon 3. The 5ʹ splice site at the boundary between exon 2 and intron 2 has been eliminated by a small deletion in the gene. Describe how the pre-mRNA encoded by this mutant gene would be spliced. Indicate which introns and exons would be found in the mRNA after splicing occurs
Question 10 0.25 pts Which of the following is true of snRNPs? They bind to the TATA box of the promoter region of a gene. They bind to splice sites at each end of the exon. They join together to form a large structure called the spliceosome. They act only in the cytosol. They attach introns to exons in the correct order. Question 11 0.25 pts Which of the following types of mutation, resulting in an error in the mRNA...
macmilan learming geneticist identify with the G-banding technique? Which mutations can a a nonsense mutation introducing a premature stop codon into a gene on chromosome 5 a single nucleotide substitution in which T replaces G on chromosome 2 a deletion of half of the long arm of chromosome 20 the long arms from two homologous chromosomes undergo a translocation an inversion of the short arm of chromosome 18
Of the following genetic variants (deletion, missense, nonsense, and splice site mutations), which types of these mutations will be detected by comparative RNA hybridization and/or comparative genomic hybridization and explain why?
1) Suppose that gene A 3,000 bp. Suppose that g contained within intron 1 opposite directions for the two genes. covers 10,000 base pairs (bp) and has 2 exons; the intron in gene A is ene B covers 1,500 bp and has two exons. Gene B is completely of gene A. The direction of the transcriptional bubble moves in A. Draw the genomic organization (i.e., exons and introns) of gene A AND gene B. Label the polarity of the DNA...
As it relates to single nucleotide polymorphism, where is the most likely location to find an SNP that does not impact protein function? Choose one: O A. within a splice site junction O B. within the middle of an intron O C. within the middle of an exon O D. within the stop codon
Most nonsense mutations in a structural gene for a protein have a null phenotype. How many different single base substitution mutations in a protein coding sequence can produce a nonsense mutation?
QUESTION 20 In a haploid, a nonsense suppressor su1 acts on mutation 1 but not on mutation 2 or 3 of gene P. An unlinked nonsense suppressor su2 works on P mutation 2 but not on 1 or 3. Explain this pattern of suppression in regard to the nature of the mutations and the suppressors. The mutations are likely frameshift mutations, resulting in three possible proteins. The suppressor mutation may be specifically complementing the protein shape of one mutant but...
3of 3 9. The figure below represents the primary transcript of a gene that contains four exons (A, B, C, D) and two introns. The dark block in exon B indicates the position of an additional stop codon; the normal start and stop codons for translation are present in exons A and D respectively. The two arrows indicate alternative 3' splice sites for the first intron Pre-mRNA 5'I 3' intron intron Give a schematic representation of the mature mRNAs that...