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3. 20% of hospitalized patients and up to 40% of patients on diuretics suffer from hypokalemia, which is abnormally low level
UNIUW HUU U U 3. 20% of hospitalized patients and up to 40% of patients on diuretics suffer from hypokalemia, which is abnorm

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Normal Potassium level in blood is 3.5 - 5 mEq/L.

Loop and thiazide diuretics increase sodium delivery to the distal segment of the distal tubules and stimulate aldosterone - sensitive sodium pump to increase sodium reabsorption in exchange for pottacium and hydrogen ion.which are lossed through the urine and results in hypokalemia.

potacium homeostasis mainly depends on renal potacium excreation.However skeletal muscles also play an important role because which contains large amount of potacium in the body. moreover due to the large number of Na+/K+ ATP ase(Na+/K+ pumps) and K+ channels, skeletal muscles pocess a huge capacity for K+ exchange.Potacium from plasma shifted to the stores and results in hypokalemia,which lead toarrythmias and sudden cardiac death.

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