the closest one is CH3NH3+ pka= 10.6 simmilar to that we have also a protonated amine with a carbon side chain.
Estimatet the pKa value of the functional group identified below by clicking on the closest pKa...
Estimate the pKa values for the functional group classes represented by the given molecule.
One of the problems with excellent data in vitro is that it is not always guaranteed to be equivalent to data in vivo. Therefore, it is important that what gives in vitro problems are resolved before getting the drug into in vivo studies to give it a better chance. For the following problems, how would you address each of the following for a target in the ER (CFTR)?1. If the drug is a small molecule with a carboxylic acid functional group...
Name this functional group The compound below contains a/an functional group.
What is the functional group formed when the reaction below occurs? What is the functional group formed when the reaction below occurs? N Select one: O A. alkene O B. ether O c. ester O D. carboxylic acid O E. alcohol
1. What easily identified type of vibration(s) (give functional group and approximate expected frequency) would be present in the IR spectrum of the isobutyraldehyde reactant but not in the product 2-methyl-3-heptanol, allowing the compounds to be distinguished? 2. What easily identified type of vibration(s) (give functional group approximate expected frequency) would be present in the IR spectrum of 2-methyl-3-heptanol but not in either of the reactants, allowing the compounds to be distinguished? 3. Does the IR spectrum of the example...
Which of the following functional groups has a pKa value of 6.14? A. carboxylic acid/carboxylate B. imidazolium/imidazole C. ammonium/ammonia
Calculate pI value of Asp (pka of COOH is 1.99 ,pka of NH3+ is 9.90 ,pKa of R group is 3.90)
The activity of an enzyme requires a glutamic acid to display its −COOH functional group in the protonated state. Suppose the pKa of the −COOH group is 4.07. At what pH will the enzyme show 82% of maximal activity?
Examples Ezetimibe pka = 1 → H+ + Clonidine pka = - > H+ + SAN3 For each: •Give the functional group name, hybridization and acidity (Acidic, Basic or Neutral) of the circled atoms Give the likely conjugate acid form in water • Estimate the pKa of circled atoms •Which one is the stronger base (blue circle) 120
Interactive Case Study # 2 Henderson Hasselbach Relationship Can you help me find the correct pKa for each compound, and explain which one is the right answer? (d) Gaba, an important neurotransmitter in the human brain, is represented in different ionization states below. Circle the most dominant form of this compound at pH-7. Show work to justify how you arrived at this answer. To help, a generic pKa table has been provided on the next page but these values can...