6. During the oxidation of acetyl-CoA through the TCA cycle, which steps involve oxidative decarboxylations?
6. During the oxidation of acetyl-CoA through the TCA cycle, which steps involve oxidative decarboxylations?
Homework Answers
During TCA cycle twice oxidative decarboxylation occurs.
1.Isocitrate getting converted in to Alpha-keto glutarate. Here one CO2 molecule gets separated from the substrate. And NAD+ gets reduced to NADH by taking reducing power from the substrate.
Loss of Co2 is called decarboxylation. Removal of Hydrogen is called oxidation.So the substrate(Isocitrate) is undergoing decarboxylation and oxidation to form alpha ketoglutaric acid.
2.When alpha keto glutaric acid becomes succenyl CoA, it again looses Co2 and reduces NAD+ in to NADH. Here also substrate is undergoing decarboxylation and oxidation.
These are the two steps when the decarboxylation and oxidation occur in TCA cycle.
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6. During the oxidation of acetyl-CoA through the TCA cycle,
which steps involve oxidative decarboxylations?
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