Question

​In a liver cell, if a single molecule of glucose undergoes glycolysis



In a liver cell, if a single molecule of glucose undergoes glycolysis, and the citrate cycle completes along with the electron transport chain, how many net ATP molecules are produced based on the chemical potential energy contained in the glucose substrate? 


Assume that no other pathways were involved.

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32 ATP - In glycolysis preparatory phase 2 ATP is spent by phosphorylation of glucose and fructose 6-phosphate. In glycolysis pay-off phase, 4 ATP is gained by substrate-level phosphorylation, and 3 or 5 ATP is gained from oxidative phosphorylation of 2 NADH. In oxidative decarboxylation of pyruvate 5 ATP is formed by oxidative phosphorylation of 2NADH. In citric acid cycle 6 NADH and 2 FADH2 are produced. 15 ATP is formed by oxidative phosphorylation from 6 NADH and 3 ATP from oxidative phosphorylation 2 FADH2 in electron transport chain. So in total the 30 - 32 ATP is formed at the end of electron transport chain.

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