Question

Complete the sentences to correctly describe steps in fatty acid synthesis.

Put the terms to the appropriate blanks. Some terms will not be used, and some will be used more than once.

Fatty acid synthesis begins with a preparatory step in which ____________ is transferred from ___________ to the ___________. However, it cannot pass through the membrane, so it is transported as ___________, which is cleaved to ____________ and ____________.

In the cytosol, acetyl CoA is converted to ____________, a three-carbon compound.

Fatty acid synthesis begins with the transfer of the acetyl group from acetyl CoA to fatty acid synthase. __________-carbon groups, supplied by __________, are added to the growing acyl chain in a series of steps involving condensation, ____________, and dehydration reactions.

Elongation of the fatty acid chain stops at __________ carbon atoms, after __________ cycles, as the free fatty acid is released.

Terms: Oxidation, 14, cytoplasm, oxaloacetate, reduction, 7, acteyl CoA, 3, malonyl ACP, citrate, malonyl CoA, 16, 2, mitochondria

Answer 1

Fatty acid synthesis begins with a preparatory step in which acetyl CoA is transferred from mitochondria to the cytosol. However, it cannot pass through the membrane, so it is transported as citrate, which is cleaved to acetyl CoA and oxaloacetate.

In the cytosol, acetyl CoA is converted to malonyl CoA, a three-carbon compound.

Fatty acid synthesis begins with the transfer of the acetyl group from acetyl CoA to fatty acid synthase. 2-carbon groups, supplied by malonyl CoA, are added to the growing acyl chain in a series of steps involving condensation, reduction, and dehydration reactions.

Elongation of the fatty acid chain stops at 16 carbon atoms, after 7 cycles, as the free fatty acid is released.