What could be a consequence of loss of proper p53 function A. Cells fail to progress...
What could be a consequence of loss of proper p53 function
A. Cells fail to progress in the cell cycle at start.
B. Mutations accumulate in somatic cells
C. M-phase cyclins are inactivated
D. DNA replication is blocked
Homework Answers
cell fails to progress in the cell cycle to start. (A)
protein p53 stimulates transcription of the gene encoding a CKI protein called p21 ; this protein binds to G1/S-CDK and S-CDK complexes and inhibits their activities, thereby helping to block entry into the cell cycle.
p53 protein is a trancription factor that regulates the expression of several genes involved in DNA repair, cell growth, apoptosis, antioxidant defence and senesscence. p53 is describeed as guardian of the genome and the cellular gatekeeper.
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What could be a consequence of loss of proper p53
function
A. Cells fail to progress...
Why do loss of function mutations in p53 often lead to mutations in other genes? See...
Why do loss of function mutations in p53 often lead to mutations in other genes? See Section 19.6 (Page) O p53 normally functions as a tumor suppressor to stop the cell cycle after DNA damage occurs. O p53 normally functions as a tumor suppressor that encourages cell growth by triggering specific phases of the cell cycle O p53 normally functions as a proto-oncogene to stop the cell cycle after DNA damage occurs. O p53 normally functions as a proto-oncogene that...
help me with that please this question is cery important i have a final , 7. Loss-of-function mutations in p53 typify the ajority of human cancers Discovery of the roles for p53 in the DNA damage...
help me with that please this question is cery important i
have a final ,
7. Loss-of-function mutations in p53 typify the ajority of human cancers Discovery of the roles for p53 in the DNA damage checkpoint and in apoptosis helps to explain its potency as a tumor suppressor protein. Recent studies suggest that p53 may possess an additional anti-tumor function: preventing telomerase activity. In one such study by Ogawa and colleagues, a human pancreatic cell line called MIA PaCa-2,...
Cancer biology 23. The levels of these proteins fluctuate dramatically as cells progress through the cell...
Cancer biology
23. The levels of these proteins fluctuate dramatically as cells progress through the cell cycle. These fluctuations are tightly coordinated with the schedule of advances through the various cell cycle phases. For a particular subtype, extracellular signals, notably those conveyed by growth factors, strongly influence their levels. These proteins are: cdc25-like phosphatases b. Cdk kinases c. Protectins d. Cyclins 24. Which of the following best describes the biochemistry that correlates to one of the cell cycle functions of...
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6.) Mitogens are (b) transcription factors important for cyclin production (c) kinases that cause cells to...
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1. Damaged DNA is discovered during the G1 checkpoint. How does p53 react, and what are...
1. Damaged DNA is discovered during the G1 checkpoint. How does p53 react, and what are the possible results? 2. If S phase checkpoints detect nucleotides deficit, what happens to the dividing cell and the cell cycle? 3. What three conditions may be detected during the G2 checkpoints, and what are the two possible results if there is inadequate DNA or spindle fibers? 4. What two conditions are checked during the metaphase checkpoint? What happens if the cell “passes” the...
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Cats are diploid organisms that have 38 chromosomes in their somatic cells during G1 phase. Based on this information, answer the following questions about the cell cycle of a cat's somatic cell: a) How many DNA double helix molecules are present in a somatic cell of a cat during G1 phase? Explain your answer. b) How many total DNA double helix molecules are present in a somatic cell of a cat during G2 phase? Explain your answer. c) Describe what...
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QUESTION 1 A gene that encodes a protein that stimulates progression of the cell cycle is known as a proto-oncogene. True False QUESTION 2 Cytokinesis occurs after which stage or phase of the cell cycle? a. G2 b. S c. G0 d. G1 e. M phase QUESTION 3 During cell-cycle checkpoints, protein kinases known as CDKs phosphorylate target proteins only when they associate with a cyclin. True False QUESTION 4 During mitosis, many of the spindle fibers attach to chromosomes...
Why do loss of function mutations in p53 often lead to mutations in other genes? See Section 19.6 (Page) O p53 normally functions as a tumor suppressor to stop the cell cycle after DNA damage occurs. O p53 normally functions as a tumor suppressor that encourages cell growth by triggering specific phases of the cell cycle O p53 normally functions as a proto-oncogene to stop the cell cycle after DNA damage occurs. O p53 normally functions as a proto-oncogene that...
help me with that please this question is cery important i
have a final ,
7. Loss-of-function mutations in p53 typify the ajority of human cancers Discovery of the roles for p53 in the DNA damage checkpoint and in apoptosis helps to explain its potency as a tumor suppressor protein. Recent studies suggest that p53 may possess an additional anti-tumor function: preventing telomerase activity. In one such study by Ogawa and colleagues, a human pancreatic cell line called MIA PaCa-2,...
Cancer biology
23. The levels of these proteins fluctuate dramatically as cells progress through the cell cycle. These fluctuations are tightly coordinated with the schedule of advances through the various cell cycle phases. For a particular subtype, extracellular signals, notably those conveyed by growth factors, strongly influence their levels. These proteins are: cdc25-like phosphatases b. Cdk kinases c. Protectins d. Cyclins 24. Which of the following best describes the biochemistry that correlates to one of the cell cycle functions of...
Question 26 (1 point) How is cytokinesis in plant cells different from cytokinesis in animal cells? Cytokinesis in plant cells requires formation of a cell plate; cytokinesis in animal cells requires formation of a ring of actin. Cytokinesis in plant cells occurs during G2; cytokinesis in animal cells occurs in the M phase of the cell cycle. Cytokinesis in plant cell results in one large cell with two nuclei; cytokinesis in animal cells results in two cells, each with one...
6.) Mitogens are (b) transcription factors important for cyclin production (c) kinases that cause cells to grow in size (a) extracellular signals that stimulate cell division. d) produced by mitotic cells to keep nearby neighboring cells from dividing 7.) Which of the following cyclins is most active during mitosis? (a) cyclin A (b) cyclin B (c) cyclin C (d) cyclin D 8) Which molecule inactivate itotic cyclin-CDK complexes using phosphorylation? (a) Cdc25 (b) Cdc6 (c) Weel (d) Helicase 9.) What...
Cats are diploid organisms that have 38 chromosomes in their somatic cells during G1 phase. Based on this information, answer the following questions about the cell cycle of a cat's somatic cell: a) How many DNA double helix molecules are present in a somatic cell of a cat during G1 phase? Explain your answer. b) How many total DNA double helix molecules are present in a somatic cell of a cat during G2 phase? Explain your answer. c) Describe what...
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