Question

You are a pharmacologist whose blind dog ate your list of compound effects and therapeutic uses. All that remains is a list of code names and the pharmacokinetic properties of each drug. Using this, describe the drug effects and therapeutic (clinical) uses for each compound. For each, briefly explain how and why these effects are produced.

a) Compound A - A barbiturate with low lipid solubility.

b) Compound B - A benzodiazepine with 3 active metabolites and poor depot binding.

c) Compound C - An alpha-2 receptor agonist.

d) Compound D - A beta-receptor antagonist.

Answer 1

a) Compound A

The barbiturates are rapidly distributed throughout the body and readily cross the blood-brain barrier. It is more hazardeous.

b) Compound B

The benzo-diazepine are closely associated with the receptors for major inhibitory neurotransmitter in the brain.

c) Compound C

It is mainly inhibits the adenylyl cyclase activity which reduces brain stem vasamotor centermediated CNS activation which is used as the antihypertensive,sedative and treatment of opiate depedence.

d) Compound D

It inhibits the function of the adrenergic receptors. It binds to beta-adrenoceptors and thereby blocks the binding of norepinephrine and epinephrine to these receptors.