Explain how reducing gastric mobility would affect the number of glucose transporters in the membranes of...

Question

Question

Explain how reducing gastric mobility would affect the number of glucose transporters in the membranes of these cells.

Answer 1

Answer #1

Gastric mobility refers to the emptying and filling of the stomach.
Reducing gastric mobility of gastric emptying (such as effects of incretin hormone) induces factors such as Glucose-dependent insulinotropic peptide (GIP).
GIP slows glucagon activity and induces insulin production.
GLUT are Glucose transporters, which act as facilitated glucose transporter.
GLUT transport glucose into the cell down its concentration gradient.
GLUT transports glucose by alternative conformation.
Glucose binding sites are present both inside and outside the transporter.
The higher concentration of glucose activates the affinity for binding of glucose to the transporter. Membrane spanning motifs prevents intra-cellular binding of glucose. Also, glucose is chemically fixed to prevent back transport.
In presence of insulin, there in rapid increase of GLUT on plasma membrane, which facilitates glucose uptake by muscle and fat cells.
Thus, reducing gastric mobility in turn increases glucose transporters.

Answer 2

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