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Epidermal growth factor is a signaling molecule that prompts cells to grow and divide. When it...

Epidermal growth factor is a signaling molecule that prompts cells to grow and divide. When it binds to a pair of receptors on the cell membrane of an epithelial cell, the receptors dimerize and eventually the molecule Raf is activated. Raf is similar to the molecule Ras that we talked about in class. Raf initiates a phosphorylation cascade of kinases. This eventually causes a change in gene expression of the cell. If Raf was defective and could not be activated, which of the following would occur? Select one or all

The cell would detect epidermal growth factor

The cell would experience a phosphorylation cascade

The cell would have a change in gene expression
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Answer #1

The cell would have a change in gene expression.

Because raf is important for the expression of the genes along with v-Src, and MEK1. Which were used to identify changes in gene expression that participate in oncogenic transformation, as well as in normal growth control.

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