If the partition coefficient of a drug between an organic solvent and water is 5, how...
If the partition coefficient of a drug between an organic solvent and water is 5, how many mg of the drug is extracted from a 120 ml of 2% aqueous solution if it was extracted with 60 ml of the organic
let mass of compound insolution = 4mg
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If the partition coefficient of a drug between an organic
solvent and water is 5, how...
Assume an organic compound has a partition coefficient between water and ether equal to 8.48. If...
Assume an organic compound has a partition coefficient between water and ether equal to 8.48. If there are initially 7.52 grams of the compound dissolved in 70.0 mL of water, how many grams will remain in the aqueous layer after extraction with two 25.0 mL portions of ether? Mass: ________ g
Question 22 of 22 > Attempt 3 Assume an organic compound has a partition coefficient between...
Question 22 of 22 > Attempt 3 Assume an organic compound has a partition coefficient between water and ether equal to 9.67. If there are initially 9.39 grams of the compound dissolved in 75.0 mL of water, how many grams will remain in the aqueous layer after extraction with two 25.0 mL portions of ether? Mass: 0,53
Assume an organic compound has a partition coefficient between water and ethyl acetate equal to 9.61....
Assume an organic compound has a partition coefficient between water and ethyl acetate equal to 9.61. If there are initially 7.33 grams of the compound dissolved in 90.0 mL of water, how many grams will remain in the aqueous layer after extraction with two 10.0 mL portions of ethyl acetate?
The partition coefficient of a drug was determined in two different solvent systems: A. Chloroform/water and...
The partition coefficient of a drug was determined in two different solvent systems: A. Chloroform/water and B. Octanol/water. Which of the following is correct about these two partition coefficient? Both partition coefficents would be same Both partition coefficents would not be same Partition coefficient of any drug determined in Octanol/water solvent system would be lower than that in chloroform/water solvent systems solubility Partition coefficient of any drug determined in Octanol/water solvent system would be greater than that in chloroform/water solvent...
Given the partition coefficient between ethyl acetate and water for Compound A is 7.0, 1. what...
Given the partition coefficient between ethyl acetate and water for Compound A is 7.0, 1. what mass of A, to the tenths place, would be extracted from a 50 mL solution of water containing 9.0 g of A using 25 mL ethyl acetate? (2 pt)
The partition coefficient, K, for compound A between toluene and water is 7.25. What is the...
The partition coefficient, K, for compound A between toluene and water is 7.25. What is the concentration of compound A remaining in the aqueous phase after 40.0 mL of 0.205 M A is extracted with each quantity of toluene indicated? one 35.0 mL portion: [A]= two 17.5 mL portions: (A)2 = five 7.00 mL portions: [A]g = ten 3.50 mL portions: [A] 20 =
In drug discovery, the value “log P” (the log of the octanol-water partition coefficient) is often...
In drug discovery, the value “log P” (the log of the octanol-water partition coefficient) is often used as an estimate of the lipophilicity of a potential new drug. log P = log([solute]octanol/[solute]water) The log P value for nicotine is 1.09. If 20 mL of 0.10 g/mL nicotine solution in water is extracted with 20 mL of octanol, how much nicotine is removed from the water layer into the octanol layer? If the same water solution is extracted with (2 x...
1) Explain how saturated NaCl solution would help draw the water away from the organic layer in the emulsion layer....
1) Explain how saturated NaCl solution would help draw the water away from the organic layer in the emulsion layer. 2) You have a solution of 30 mg of caffeine dissolved in 100 mL of water. The partition coefficient for aqueous caffeine extracted with Dichloromethane (CH2C12) is 4.6. Show all work for the following calculations: a. Calculate the total mg extracted by using a single 30 mL portion of dichloromethane. b. Calculate the total mg extracted by using a three...
Solute X has a partition coefficient of 4.5 between water (phase 1) and chloroform (phase 2)....
Solute X has a partition coefficient of 4.5 between water (phase 1) and chloroform (phase 2). The solute is initially dissolved in 50.0 mL. It is then extracted with 10.0 mL portions of chloroform. How many extractions must be performed for < 0.1% of X to remain in the water phase, i.e., > 99.9% of X has been transferred to the aqueous phase.
Solute A has a partition coefficient of 8 between toluene and water. Suppose that 350 mL...
Solute A has a partition coefficient of 8 between toluene and water. Suppose that 350 mL of a 0.01 M aqueous solution of A are extracted with toluene. What would be the extraction efficiency (R%) if 2 extractions with 50 mL toluene were performed? (Keep one decimal place in your final answer.)
Question 22 of 22 > Attempt 3 Assume an organic compound has a partition coefficient between water and ether equal to 9.67. If there are initially 9.39 grams of the compound dissolved in 75.0 mL of water, how many grams will remain in the aqueous layer after extraction with two 25.0 mL portions of ether? Mass: 0,53
The partition coefficient of a drug was determined in two different solvent systems: A. Chloroform/water and B. Octanol/water. Which of the following is correct about these two partition coefficient? Both partition coefficents would be same Both partition coefficents would not be same Partition coefficient of any drug determined in Octanol/water solvent system would be lower than that in chloroform/water solvent systems solubility Partition coefficient of any drug determined in Octanol/water solvent system would be greater than that in chloroform/water solvent...
Given the partition coefficient between ethyl acetate and water for Compound A is 7.0, 1. what mass of A, to the tenths place, would be extracted from a 50 mL solution of water containing 9.0 g of A using 25 mL ethyl acetate? (2 pt)
The partition coefficient, K, for compound A between toluene and water is 7.25. What is the concentration of compound A remaining in the aqueous phase after 40.0 mL of 0.205 M A is extracted with each quantity of toluene indicated? one 35.0 mL portion: [A]= two 17.5 mL portions: (A)2 = five 7.00 mL portions: [A]g = ten 3.50 mL portions: [A] 20 =
1) Explain how saturated NaCl solution would help draw the water away from the organic layer in the emulsion layer. 2) You have a solution of 30 mg of caffeine dissolved in 100 mL of water. The partition coefficient for aqueous caffeine extracted with Dichloromethane (CH2C12) is 4.6. Show all work for the following calculations: a. Calculate the total mg extracted by using a single 30 mL portion of dichloromethane. b. Calculate the total mg extracted by using a three...
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