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Describe the innate immune response of Rift Valley Fever. How did the pathogen try to fight...

Describe the innate immune response of Rift Valley Fever. How did the pathogen try to fight (both typical and specific to this pathogen)? And what did the pathogen do to save itself?

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Rift Valley Fever (RVF) is caused by an emerging arbovirus endemic in sub-Saharan African countries. RVF virus (RVFV) may spread as a result of the movement of infected animals.

Goats developed viremia one day post infection (DPI), which lasted three to four days and some goats had transient fever coinciding with peak viremia.

Infected goats produced serum IFN-γ, IL-12 and other proinflammatory cytokines but not IFN-α. Despite the lack of IFN-α, innate immunity via the IL-12 to IFN-γ circuit possibly contributed to early protection against RVFV since neutralising antibodies were detected after viremia had cleared.

It induces fever and affects specific immune cell subpopulations.

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