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Describe in one paragraph which gene you think is mutated and why, based on the information...

Describe in one paragraph which gene you think is mutated and why, based on the information in Flybase. Include the name of the gene, its function and your rationale for why you believe it is mutated in your flies? (The gene dmel/hsf is mutated because the mutated alleles exhibits compromised thermotolerance)

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Answer #1

The dmel/hsf is the gene which is considered to be mutated. The gene is present in the fly and it is a heat shock factor. This means that it helps in preventing the fly from heat shock and hence to an extent makes it thermotolerance. The Hsf is a heat shock factor protein and it tends to bind to the heat shock promoter element which helps in activating the transcription and as the HSE is activated, it helps in proving thermotolerance. However, when there is a mutation, the proteins is not able to bind to the HSE and hence leads to compromised thermotolerance. Since the HSE is not longer activated, it does not allow any further resistance towards temperature.

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