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A mutation in CheA (histidine kinase) reduces swimming motility. A second mutation in CheY restores swimming...

A mutation in CheA (histidine kinase) reduces swimming motility. A second mutation in CheY restores swimming motility to wild type levels. What type of mutation is the mutation in CheY?

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Answer #1

Answer: Suppressor mutation
Explanation:
Second-site mutation: A mutation at a second locus that affects the function of the first/initial locus
The second site mutation can be an enhancer i.e. activates the function of the first gene
The second site mutation can be a suppressor i.e. represses the function of the first gene

In the given case, loss of function of CheA phenotype is suppressed by mutation at the CheY locus.
The mutation at the CheY locus can be dominant mutation which does not require the function of CheA (i.e. may get activated even without phosphorylation)

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