Question

why is not always possible to detect a microbial pathogen in a patient?

Answer 1

ANSWER

In some cases, despite the strong suggestion of a microbial etiology, conventional diagnostic methods cannot determine the cause. The dramatic nature of these illnesses belies their potential importance to public health and their value in revealing emerging agents of cause.

Pathogens that may be difficult to detect or identify:

1.Pathogens that establish intimate relationships with the hosts, endosymbionts and intracellular organisms.

2.Chimeras natural versus man-made.

3."Nonpathogens " that acquire virulence-associated genes.

4. Microorganisms without "universal" sequences.