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briefly explain the abnormal accumulation of metabolites in urine terms of overflow renal disorders

briefly explain the abnormal accumulation of metabolites in urine terms of overflow renal disorders
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Substances involved in the metabolism of protein, fat, carbohydrates. These substances get deposited in the blood due to the disruption of any normal metabolic pathway. This includes

phenylketonuria- PKU is caused by failure to inherit the gene to produce the enzyme phenylalanine hydroxylase.
Tyrosyluria- It is accumulation of tyrosine in the plasma.
Alkaptonuria- This is due to the failure to produce the enzyme homogentisic acid.

Melanuria- It is due to the presence of melanin in the urine.
Cystinuria- Elevated levels of cystine in the blood.

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