Question

The liver can absorb cholesterol from peripheral tissues via the blood. This process is known as reverse cholesterol transport. Which is considered to be the quantitatively most significant way in which liver hepatocytes take up cholesterol from human peripheral tissue?

a. Cholesterol is amphipathic and circulates in the blood freely or bound to globulins, from which it is primarily taken up by the hepatocytes by direct incorporation into the plasma membrane.

b. Cholesterol is primarily taken up by endocytosis of cholesterol ester-rich LDL particles and chylomicron remnants via the LDL receptor and LDL receptor-related protein.

c. Cholesterol is taken up primarily by lipoprotein lipase-catalyzed hydrolysis of cholesterol esters in triglyceride and cholesteryl ester rich VLDL particles and chylomicrons.

d. Cholesterol is amphipathic and circulates in the blood, freely or bound to globulins, from which it is primarily taken up by the hepatocytes by transport proteins in the plasma membrane.

e. Cholesterol is taken up primarily from HDL particles that are cleared of cholesterol by binding to Scavenger Receptor B1 in the hepatocytes.

Answer 1

The correct answer is Point e that is Cholesterol is taken up primarily from HDL particles that are cleared of cholesterol by binding to Scavenger Receptor B1 in the hepatocytes.