Explain the regulation and role of phosphofuctokinase-2 and fructose 2,6-bisphosphatase with respect to blood sugar levels...
Explain the regulation and role of phosphofuctokinase-2 and fructose 2,6-bisphosphatase with respect to blood sugar levels and glycolysis/gluconeogenesis.
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Explain the regulation and role of phosphofuctokinase-2 and
fructose 2,6-bisphosphatase with respect to blood sugar levels...
After eating, elevated levels of fructose 6-phosphate will stimulate ["phosphoprotein phosphatase or Protein kinase A (PKA)"]....
After eating, elevated levels of fructose 6-phosphate will stimulate ["phosphoprotein phosphatase or Protein kinase A (PKA)"]. This causes the dephosphorylation of the the phosphofructokinase 2/fructose 2,6-bisphosphate polypeptide to stimulate the activity of ["phosphofructokinase 2 or fructose 2,6-bisphosphatase"].This results in an increase of ["fructose 6-phosphate or fructose 2,6-bisphosphate"] and activation of ["glycolysis or gluconeogenesis"] . Choose one of the answers in the brackets.
D) Now let's think about the role of fructose 2,6-bisphosphate and the role of glucagon in...
D) Now let's think about the role of fructose 2,6-bisphosphate and the role of glucagon in stimulating liver cells to make and secrete glucose to the blood. in the level of fructose 2,6-bisphosphate. High glucagon would cause a(an) (Write either “increase” or “decrease” in that blank.) What enzyme does fructose 2,6-bisphosphate ACTIVATE? E) OK, let's go back to the first of those glycolysis steps that you said was highly regulated. Using THERMODYNAMICS terms, what is it about this reaction that...
This discussion focuses on the regulation of glycolysis and gluconeogenesis by phosphofructokinase-2 and will help you...
This discussion focuses on the regulation of glycolysis and
gluconeogenesis by phosphofructokinase-2 and will help you apply
your understanding of these pathways and their regulation to
adaptations in cancerous cells.
You have successfully completed your internship rotation
with the antibiotic group at
MethylTranspharmiX and have moved into
their Cancer Therapeutics division.
In many cancers, cells use aerobic glycolysis rather than
oxidative phosphorylation as their main energy source. This is
known as the Warburg effect, and was first described by Otto...
Make sure to do this CORRECTLY and diligently C) For each of these reactions, name the...
Make sure to do this CORRECTLY and diligently
C) For each of these reactions, name the key enzyme that bypasses that step during gluconeogenesis. Glycolysis Reaction # Gluconcogenesis enzyme Glycolysis Reaction # Gluconeogenesis enzyme Glycolysis Reaction # Gluconeogenesis enzyme D) Now let's think about the role of fructose 2,6-bisphosphate and the role of glucagon in stimulating liver cells to make and secrete glucose to the blood. High glucagon would cause aan) in the level of fructose 2,6-bisphosphate. (Write either increase"...
Explain in detail how PFK-1, hexokinase, glucokinase, pyruvate kinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase-1, pyruvate carboxylase & PEPCK are...
Explain in detail how PFK-1, hexokinase, glucokinase, pyruvate kinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase-1, pyruvate carboxylase & PEPCK are regulated & compare their regulation in liver vs. skeletal muscle & brain when blood glucose levels are high (i.e. a fed state) & low (i.e. a fasting or starvation state).
38. Which protein is not the immediate target of glucagon-derived signal transduction events for the regulation...
38. Which protein is not the immediate target of glucagon-derived signal transduction events for the regulation of blood glucose levels? A) Glycogen phosphorylase B) Glucose-6-phosphate dehydrogenase C) Isocitrate dehydrogenase D) 6-phophofructo-2-kinase/fructose-2,6-bisphosphatase
please answer all questions. thank you A) List, in order, the three enzymes that catalyze the...
please answer all questions. thank you
A) List, in order, the three enzymes that catalyze the highly regulated steps in glycolysis. (Don't just enter 1, 2, 3 for reaction numbers - give the reaction number based on the 10 steps of glycolysis.) Reaction # Enzyme Reaction # Enzyme Reaction # Enzyme B) For each of these reactions, name ONE allosteric regulator of the enzyme and whether that regulator inhibits or activates the enzyme. Reaction # allosteric regulator allosteric regulator Inhibitor...
PART A OPTIONS FOR BLANKS: 1- inhibits, does not affect, stimulates 2- fructose-1,6-biphosphatase-1, pyruvate kinase, phosphofructokinase-1...
PART A OPTIONS FOR BLANKS:
1- inhibits, does not affect, stimulates
2- fructose-1,6-biphosphatase-1, pyruvate kinase,
phosphofructokinase-1
3- phosphofructokinase-1, fructose-1,6-biphosphatase-1,
phosphoenolpyruvate carboxylate
PART B OPTIONS FOR BLANK:
Activity Curve A, Neither, Activity Curve B
Part 1 (3 points) See Hint High levels of fructose-2,6-BP reciprocally regulate glycolysis and gluconeogenesis. Fructose-2,6-BP flux through the glycolytic pathway by increasing the activity of Flux through the gluconeogenic pathway is inhibited by fructose-2,6- BP, which decreases the activity of Part 2 (1 point) See Hint...
When the blood glucose concentration is low, the pancreas secretes glucagon to signal the liver to...
When the blood glucose concentration is low, the pancreas secretes glucagon to signal the liver to produce glucose and glucose-1-phosphate. Which metabolic steps are involved in this biosignaling pathway? Inactivation of glycogen synthase via phosphorylation by protein kinase A Activation of glycogen synthase via phosphorylation by protein kinase A Activation of phosphofructokinase-2 via phosphorylation by protein kinase A Activation of fructose-2,6-bisphosphatase via phosphorylation by protein kinase A Activation of phosphofructokinase-1 by fructose-2,6-bisphosphate Inhibition of fructose-1,6-bisphosphatase by fructose-2,6-bisphosphate Inactivation of pyruvate...
When blood glucose levels are low, glucagon is secreted. Which of the following are the effects...
When blood glucose levels are low, glucagon is secreted. Which of the following are the effects of increased glucagon levels on glycosis and related reactions in liver ? A. Concentrations of F26BP are decreased B. Dephosphorylation of phosphofructokinase 2 and fructose bisphosphatase 2 occurs C. Glycosis is accelerated D. Glycosis is slowed down E. Phosphorylation of phosphofructokinade 2 and fructose bisphosphatase 2 occurs F. Concentrations of F26BP are increased I believe D & E , please explain and list any...
D) Now let's think about the role of fructose 2,6-bisphosphate and the role of glucagon in stimulating liver cells to make and secrete glucose to the blood. in the level of fructose 2,6-bisphosphate. High glucagon would cause a(an) (Write either “increase” or “decrease” in that blank.) What enzyme does fructose 2,6-bisphosphate ACTIVATE? E) OK, let's go back to the first of those glycolysis steps that you said was highly regulated. Using THERMODYNAMICS terms, what is it about this reaction that...
This discussion focuses on the regulation of glycolysis and
gluconeogenesis by phosphofructokinase-2 and will help you apply
your understanding of these pathways and their regulation to
adaptations in cancerous cells.
You have successfully completed your internship rotation
with the antibiotic group at
MethylTranspharmiX and have moved into
their Cancer Therapeutics division.
In many cancers, cells use aerobic glycolysis rather than
oxidative phosphorylation as their main energy source. This is
known as the Warburg effect, and was first described by Otto...
Make sure to do this CORRECTLY and diligently
C) For each of these reactions, name the key enzyme that bypasses that step during gluconeogenesis. Glycolysis Reaction # Gluconcogenesis enzyme Glycolysis Reaction # Gluconeogenesis enzyme Glycolysis Reaction # Gluconeogenesis enzyme D) Now let's think about the role of fructose 2,6-bisphosphate and the role of glucagon in stimulating liver cells to make and secrete glucose to the blood. High glucagon would cause aan) in the level of fructose 2,6-bisphosphate. (Write either increase"...
38. Which protein is not the immediate target of glucagon-derived signal transduction events for the regulation of blood glucose levels? A) Glycogen phosphorylase B) Glucose-6-phosphate dehydrogenase C) Isocitrate dehydrogenase D) 6-phophofructo-2-kinase/fructose-2,6-bisphosphatase
please answer all questions. thank you
A) List, in order, the three enzymes that catalyze the highly regulated steps in glycolysis. (Don't just enter 1, 2, 3 for reaction numbers - give the reaction number based on the 10 steps of glycolysis.) Reaction # Enzyme Reaction # Enzyme Reaction # Enzyme B) For each of these reactions, name ONE allosteric regulator of the enzyme and whether that regulator inhibits or activates the enzyme. Reaction # allosteric regulator allosteric regulator Inhibitor...
PART A OPTIONS FOR BLANKS:
1- inhibits, does not affect, stimulates
2- fructose-1,6-biphosphatase-1, pyruvate kinase,
phosphofructokinase-1
3- phosphofructokinase-1, fructose-1,6-biphosphatase-1,
phosphoenolpyruvate carboxylate
PART B OPTIONS FOR BLANK:
Activity Curve A, Neither, Activity Curve B
Part 1 (3 points) See Hint High levels of fructose-2,6-BP reciprocally regulate glycolysis and gluconeogenesis. Fructose-2,6-BP flux through the glycolytic pathway by increasing the activity of Flux through the gluconeogenic pathway is inhibited by fructose-2,6- BP, which decreases the activity of Part 2 (1 point) See Hint...
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