Give one similarity and one difference between a monomeric G-protein (such as Ras GTPase) involved in...
Give one similarity and one difference between a monomeric G-protein (such as Ras GTPase) involved in enzyme-linked receptor signaling versus the alpha subunit of a heterotrimeric G-protein involved in GPCR signaling.
Homework Answers
Both alpha subunit of a heterotrimeric protein and monomeric G protein (Ras) are required GTP bound form for their function. The alpha subunit of heterotrimeric G protein and monomeric G protein has intrinsic GTPase activity, they can hydrolyze GTP into GDP and convert into GDP bound form or inactive form.
The monomeric G protein differ from the alpha subunit of heterotrimeric G protein, they have a weak GTP hydrolyzing activity, require some other proteins GTPase activating protein (GTP) for GTP hydrolysis whereas alpha subunit can hydrolyze GTP by itself.
Monomeric G proteins also require guanine exchange factor-like sos for their activation which stimulate the release of GDP from Ras and helps in its activation, heterotrimeric G protein alpha subunit does not require any such protein for exchange of GDP into GTP.
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Give one similarity and one difference between a monomeric
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The small monomeric G protein Ras is an important component of most receptor tyrosine kinase signaling pathways. It can regulate a number of downstream signaling components, perhaps most famously the MAPK cascade. Unlike other monomeric G proteins that we have discussed previously in class, Ras is anchored at the plasma membrane by a covalently bound lipid anchor. If Ras was specifically mutated so that it did not get this lipid modification (but was otherwise completely unchanged), what do you hypothesize...
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The small monomeric G protein Ras is an important component of most receptor tyrosine kinase signaling pathways. It can regulate a number of downstream signaling components, perhaps most famously the MAPK cascade. Unlike other monomeric G proteins that we have discussed previously in class, Ras is anchored at the plasma membrane by a covalently bound lipid anchor. If Ras was specifically mutated so that it did not get this lipid modification (but was otherwise completely unchanged), what do you hypothesize...
4. The protein shown below is an enzyme-linked receptor. This means that this protein... Circle your answer a) can speed up chemical reactions. b) can bind to certain signaling molecules. c) all of the above. D. Think about the enzyme-linked receptor we discussed in class. After the signaling molecules binds to this receptor, it causes the active site on the receptor to become available. What binds to this active site? E. Consider the molecule you named in the previous question....
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