1. What is the difference between: a. A G Protein and G Protein-Coupled Receptor b. Trimeric...
Homework Answers
Trimeric G proteins: They have alpha, beta and gamma subunits. These trimeric G proteins are associated with cell surface receptor signaling. They bind GTP, dissociates and interacts with an effector.
Monomeric G proteins: They are receptor linked belong to Ras family. They are small GTPases. They bing GTP, interact with effectors, promote various cellular processes.
A G protein: acts as an on/off switch : If GDP is bound to G protein, the G protein is inactive.
G-protein coupled receptor: Large family of integral membrane protein involved in many biological processes.Bind their ligand and to activate different G proteins. It is a plasma membrane receptor that works with the help of a G protein.
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1. What is the difference between:
a. A G Protein and G Protein-Coupled Receptor
b. Trimeric...
3. Think about what G-proteins look like before they bind to a G-protein-coupled receptor. These G-proteins...
3. Think about what G-proteins look like before they bind to a G-protein-coupled receptor. These G-proteins would have...circle your answer GTP attached to them OR GDP attached to them (a) Think about what G-proteins look like after they bind to a G-protein-coupled receptor. These G-proteins would have...circle your answer GTP attached to them OR GDP attached to them (b) A molecule of GTP contains how many phosphate groups? (c) Think about a G-protein that has a GTP attached to it....
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein...
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein and then the receptor deactivates. O True False When an activated receptor relays the signal along more than one pathways this is called convergence. O True OFalse Which of the following best describes digestive enzymes? O Hydrolases OLigases Kinases Transferases Decarboxylases Most digestive enzymes are released from cells in an inactive form. True False denatures Protein digestion in humans (and other mammals) begins in...
4. What type of membrane protein is this G-protein Coupled Receptor (GPCR) integral or peripheral) and...
4. What type of membrane protein is this G-protein Coupled Receptor (GPCR) integral or peripheral) and describe the features that contribute to its function in the cell? 5. How does the low GTPase activity in the mutated protein result in the constitutive activation of the G a protein and adenylate cyclase?
Insulin binds to a receptor that_ I. is coupled to a G protein II. possesses tyrosine...
Insulin binds to a receptor that_ I. is coupled to a G protein II. possesses tyrosine kinase activity III. possesses serine/threonine phosphatase activity IV. interacts with proteins such as IRS-1 I, IV I, III II, IV Oll only I, II, III
Give one similarity and one difference between a monomeric G-protein (such as Ras GTPase) involved in...
Give one similarity and one difference between a monomeric G-protein (such as Ras GTPase) involved in enzyme-linked receptor signaling versus the alpha subunit of a heterotrimeric G-protein involved in GPCR signaling.
Diagram the activation of the 5-HT Serotonin Receptor (G-Protein Coupled Receptor) leading to transcriptional activation in...
Diagram the activation of the 5-HT Serotonin Receptor (G-Protein Coupled Receptor) leading to transcriptional activation in a neuron. Include signaling pathways you have learned about in lecture or in your reading that involve G-Protein Coupled Receptors and lead to gene activation. Demonstrate how Lithium acts to disrupt one of these signaling pathways.
Diagram the activation of the 5-HT Serotonin Receptor (G-Protein Coupled Receptor) leading to transcriptional activation in...
Diagram the activation of the 5-HT Serotonin Receptor (G-Protein Coupled Receptor) leading to transcriptional activation in a neuron. Include signaling pathways you have learned about in lecture or in your reading that involve G- Protein Coupled Receptors and lead to gene activation. Demonstrate how Lithium acts to disrupt one of these signaling pathways. (20 points) 5.
Which of the following mutations to the G alpha protein could render a G protein–coupled receptor...
Which of the following mutations to the G alpha protein could render a G protein–coupled receptor signaling pathway constitutively active? a G alpha cannot bind G beta/gamma b G alpha cannot hydrolyze GTP c G alpha protein cannot bind GDP d G alpha protein cannot release GDP e G alpha protein cannot bind GTP
Only one G protein molecule can be activated by a single G protein-coupled receptor. True O...
Only one G protein molecule can be activated by a single G protein-coupled receptor. True O False Prosius
1. Explain the difference between activation of g-protein coupled recepetor activation and direct gene activation. A....
1. Explain the difference between activation of g-protein coupled recepetor activation and direct gene activation. A. Which one happens faster? B. Which one lasts longer?
3. Think about what G-proteins look like before they bind to a G-protein-coupled receptor. These G-proteins would have...circle your answer GTP attached to them OR GDP attached to them (a) Think about what G-proteins look like after they bind to a G-protein-coupled receptor. These G-proteins would have...circle your answer GTP attached to them OR GDP attached to them (b) A molecule of GTP contains how many phosphate groups? (c) Think about a G-protein that has a GTP attached to it....
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein and then the receptor deactivates. O True False When an activated receptor relays the signal along more than one pathways this is called convergence. O True OFalse Which of the following best describes digestive enzymes? O Hydrolases OLigases Kinases Transferases Decarboxylases Most digestive enzymes are released from cells in an inactive form. True False denatures Protein digestion in humans (and other mammals) begins in...
4. What type of membrane protein is this G-protein Coupled Receptor (GPCR) integral or peripheral) and describe the features that contribute to its function in the cell? 5. How does the low GTPase activity in the mutated protein result in the constitutive activation of the G a protein and adenylate cyclase?
Insulin binds to a receptor that_ I. is coupled to a G protein II. possesses tyrosine kinase activity III. possesses serine/threonine phosphatase activity IV. interacts with proteins such as IRS-1 I, IV I, III II, IV Oll only I, II, III
Diagram the activation of the 5-HT Serotonin Receptor (G-Protein Coupled Receptor) leading to transcriptional activation in a neuron. Include signaling pathways you have learned about in lecture or in your reading that involve G- Protein Coupled Receptors and lead to gene activation. Demonstrate how Lithium acts to disrupt one of these signaling pathways. (20 points) 5.
Only one G protein molecule can be activated by a single G protein-coupled receptor. True O False Prosius
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