Direct gene activation directly influences gene expression & is located within the nucleus, nuclear receptors bind directly to DNA to regulate genes expression whereas, in g-protein coupled receptor activation, activity is mediated & amplified within the cells bypass the action of second messenger mechanism
A) Direct gene activation is faster
B) Direct gene activation last longer as G protein coupled receptor activation depends on the concentration of hormone in the blood.
1. Explain the difference between activation of g-protein coupled recepetor activation and direct gene activation. A....
Diagram the activation of the 5-HT Serotonin Receptor (G-Protein Coupled Receptor) leading to transcriptional activation in a neuron. Include signaling pathways you have learned about in lecture or in your reading that involve G-Protein Coupled Receptors and lead to gene activation. Demonstrate how Lithium acts to disrupt one of these signaling pathways.
Diagram the activation of the 5-HT Serotonin Receptor (G-Protein Coupled Receptor) leading to transcriptional activation in a neuron. Include signaling pathways you have learned about in lecture or in your reading that involve G- Protein Coupled Receptors and lead to gene activation. Demonstrate how Lithium acts to disrupt one of these signaling pathways. (20 points) 5.
1. What is the difference between: a. A G Protein and G Protein-Coupled Receptor b. Trimeric and Monomeric G proteins
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein and then the receptor deactivates. O True False When an activated receptor relays the signal along more than one pathways this is called convergence. O True OFalse Which of the following best describes digestive enzymes? O Hydrolases OLigases Kinases Transferases Decarboxylases Most digestive enzymes are released from cells in an inactive form. True False denatures Protein digestion in humans (and other mammals) begins in...
3. Think about what G-proteins look like before they bind to a G-protein-coupled receptor. These G-proteins would have...circle your answer GTP attached to them OR GDP attached to them (a) Think about what G-proteins look like after they bind to a G-protein-coupled receptor. These G-proteins would have...circle your answer GTP attached to them OR GDP attached to them (b) A molecule of GTP contains how many phosphate groups? (c) Think about a G-protein that has a GTP attached to it....
What is the difference between one-gene/one-protein hypothesis and one-gene/one-polypeptide hypothesis?
G-protein coupled receptors can exhibit which of the following actions? Select one: a. Dimerization b. Tyrosine kinase activity c. Nuclear Localization d. Activation of Adenylate Cyclase e. ATPase activity
7. Explain the difference between gene duplication and divergence, and the role of each. Give one example of a protein that demonstrates this process.
Which type of receptors do steroid hormones generally employ? O G-protein coupled receptors O enzyme-coupled receptors nuclear receptors O ion-channel coupled receptors What type of cell response would take the longest amount of time (on the scale of minutes to hours) to execute? one that involves the release of secretory vesicles one that stimulate lamellipodia formation by regulating the actin cytoskeleton one that involves a change in gene expression one that uses a phosphorylation event to activate an enzyme
Which of the following mutations to the G alpha protein could render a G protein–coupled receptor signaling pathway constitutively active? a G alpha cannot bind G beta/gamma b G alpha cannot hydrolyze GTP c G alpha protein cannot bind GDP d G alpha protein cannot release GDP e G alpha protein cannot bind GTP