What type of genes must be introduced to the somatic cells to engineer iPSC?
What type of genes must be introduced to the somatic cells to engineer iPSC?
Homework Answers
iPSCs can be generated by introducing certain genes that are required for reprogramming a somatic cell into a pluripotent cell. Yamanaka group who received Nobel prize for induced pluripotent stem cell has described factors that are responsible for doing so. These factors include genes and cytokines. These genes are cMyc, Klf4, Oct3/4, and Sox2. However, there may certain other groups of genes that may be capable of doing. The introduction of genes into somatic cells requires fusion with the Sendai virus. NANOG, LIN28, DPPB5, TDGF expression used as a marker to confirm the induction to pluripotent cells.
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What type of genes must be introduced to the somatic cells to
engineer iPSC?
What would be the likely result of activation of telomerase in somatic cells? A) immediate cell...
What would be the likely result of activation of telomerase in somatic cells? A) immediate cell death B) Nothing, as somatic cells already have active telomeres C) Cells capable of continuous division D) premature aging of the cell E) Cells displaying extensive DNA rearrangement and mutation
what does telomerase enable cancer cells to do the normal adult somatic cells cannot do?
what does telomerase enable cancer cells to do the normal adult somatic cells cannot do?
1a. In comparing somatic cells and gamete, somatic cells are: a. diploid with twice the #...
1a. In comparing somatic cells and gamete, somatic cells are: a. diploid with twice the # of chromosomes b. haploid with half the # of chromosomes c. none of the responses are correct d. diploid with half the # of chromosomes e. haploid with twice the # of chromosomes ------------------------------------------------------------------------------------------------------------------------------------------------ 1b. Which of the following mitosis phases is essentially the opposite of prophase in terms of nuclear changes a. metaphase b. anaphase c. cytokinesis d. telophase ------------------------------------------------------------------------------------------------------------------------------------ 1c. Gene S...
What happens during development when only certain genes are expressed in certain cells? a. The cells...
What happens during development when only certain genes are expressed in certain cells? a. The cells have become mutated, so if the organism lives, it cannot function normally. b. The cells can only perform certain functions and only pass the genes for those functions to their daughter cells. c. The cells differentiate into type of tissues and organs specialized for their functions. d. The cells cannot perform all of the functions necessary for life, and they die.
To create a viral vector for delivery of genes into mammalian cells, the virus must first...
To create a viral vector for delivery of genes into mammalian cells, the virus must first be engineered to remove: a. viral coat proteins. b. all viral genes, replacing them with the mammalian genes to be delivered. c. viral genes involved with virus replication and add mammalian genes to be delivered. d. the viral genome and coat proteins and replace them with recombinant plasmids carrying the mammalian genes to be delivered.
Suppose that a human zygote begins life with 1500 telomere repeats. Most somatic cells lose telomeres...
Suppose that a human zygote begins life with 1500 telomere repeats. Most somatic cells lose telomeres at every mitotic cell division. Further suppose that a cell begins to lose essential genes (non-telomere sequences) from its ends after 50 cell generations.How many cells are produced from one precursor cell after 50 cell generations, assuming that all cells survive? On average, how many telomeres are lost at each mitosis? Explain why telomeres are lost in the context of the question.
Il. Define and give examples of Chromosomes (how many are in normal human somatic cells, how...
Il. Define and give examples of Chromosomes (how many are in normal human somatic cells, how many in gametes?) Karyotype Describe the karyotypes of normal male, normal female, Down syndrome, Turners Syndrome and Klinefelter's Syndrome Define "autosomes" and "sex chromosomes" Define and give an example: A. Gene B. Allele C. Dominant Allele D. Recessive Allele E. Incomplete mode of inheritance F. Co-dominant alleles G. Sex-inked genes
Cats are diploid organisms that have 38 chromosomes in their somatic cells during G1 phase. Based...
Cats are diploid organisms that have 38 chromosomes in their somatic cells during G1 phase. Based on this information, answer the following questions about the cell cycle of a cat's somatic cell: a) How many DNA double helix molecules are present in a somatic cell of a cat during G1 phase? Explain your answer. b) How many total DNA double helix molecules are present in a somatic cell of a cat during G2 phase? Explain your answer. c) Describe what...
What happens during development when only certain genes are expressed in certain cells? A. The cells...
What happens during development when only certain genes are expressed in certain cells? A. The cells can only perform certain functions and only pass the genes for those functions to their daughter cells. B. The cells differentiate into types of tissues and organs specialized for their functions. C. The cells have become mutated, so if the organism lives, it cannot function normally. D. The cells cannot perform all of the functions necessary for life, and they die.
(a) Somatic mutation typically occurs in sex cells. decreases with maternal age. shows that each of...
(a) Somatic mutation typically occurs in sex cells. decreases with maternal age. shows that each of us does not have a single, permanent genotype. takes place in the cells that give rise to gametes. (b) These three things describe how genes affect the environments to which people are exposed. (c) If a family history of mental retardation, psychological disorders, physical defects, or inherited diseases exists, a genetic counselor prepares a __________, which identifies affected relatives in a couple s family...
Il. Define and give examples of Chromosomes (how many are in normal human somatic cells, how many in gametes?) Karyotype Describe the karyotypes of normal male, normal female, Down syndrome, Turners Syndrome and Klinefelter's Syndrome Define "autosomes" and "sex chromosomes" Define and give an example: A. Gene B. Allele C. Dominant Allele D. Recessive Allele E. Incomplete mode of inheritance F. Co-dominant alleles G. Sex-inked genes
Cats are diploid organisms that have 38 chromosomes in their somatic cells during G1 phase. Based on this information, answer the following questions about the cell cycle of a cat's somatic cell: a) How many DNA double helix molecules are present in a somatic cell of a cat during G1 phase? Explain your answer. b) How many total DNA double helix molecules are present in a somatic cell of a cat during G2 phase? Explain your answer. c) Describe what...
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