Changes in protein expression can alter gene function since: High levels of protein mean that the...
Changes in protein expression can alter gene function since:
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High levels of protein mean that the protein can sustain mutations more readily without any harm to the cell. |
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The cell responds only to high levels of protein. |
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Changes in expression can alter regulatory networks. |
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Low levels of protein mean that the protein can sustain mutations more readily without any harm to the cell. |
The mutations found in the CF gene that result in cystic fibrosis are recessive because:
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The CF mutations that occur result in no protein being produced. |
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Normal or near normal cellular function can occur from the protein produced by the normal allele. |
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CF is fatal and if the alleles that caused CF were dominant it would not be inherited. |
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CF mutations only result in a protein that has normal function if there is also a normal CF protein in the cell. |
Homework Answers
1. Changes in expression can alter regulatory networks.
2. Normal or near normal cellular function can occur from the protein produced by the normal allele
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Changes in protein expression can alter gene function since:
High levels of protein mean that the...
Mutations in the exons of eukaryotic genes can result in changes in the translated protein. Nonexonic...
Mutations in the exons of eukaryotic genes can result in changes in the translated protein. Nonexonic mutations, mutations in regions of a gene outside of the exons, can also alter the rate of transcription and the final protein. In which of the following situations would nonexonic mutations either affect expression of the gene or alter the structure of the final protein? Select all of the statements that apply.
please help 6. How can a missense mutation-such as in sickle cell disease-result in a protein...
please help
6. How can a missense mutation-such as in sickle cell disease-result in a protein that has an abnormal structure? Some of these mutations are lethal or cause serious disease, such as cystic fibrosis and sickle cell disease. Many of these point mutations that cause genetic disorders occur as a result of errors in DNA replication or crossing over. 7. What will be the consequence if a single base is deleted from the coding region of a gene?
Suppose scientists studying pigmentation in Arabidopsis attempted to alter expression of a pigment gene. Using transgenic...
Suppose scientists studying pigmentation in Arabidopsis attempted to alter expression of a pigment gene. Using transgenic techniques, multiple copies of the pigment gene were inserted into homozygous and heterozygous individuals. This was expected to darken the pigmentation of the plants. Instead of increased pigment production, the additional gene copies often reduced or completely inhibited the pigment gene expression. One explanation for this unexpected result is that high concentrations of mRNA are produced. This, in turn, increases the likelihood of homologous...
For Questions 4-18, consider the mutations described in the left-hand column below. Identify whether the Lac operon will be ON or OFF in each of the environments listed across the top. The expression...
For Questions 4-18, consider the mutations described in the left-hand column below. Identify whether the Lac operon will be ON or OFF in each of the environments listed across the top. The expression of the normal (wild type) operon is given. Note that "ON" and "OFF" refer to whether the operon is expressed at high levels (ON) or basal//low/no levels (OFF). (Hint: mutations render the indicated site inactive while leaving the remaining part of the operon or protein functional.) Note...
3. (2 points) In the nematode roundworm, Caenorhabditis elegans, the LIN-14 protein controls the timing of...
3. (2 points) In the nematode roundworm, Caenorhabditis elegans, the LIN-14 protein controls the timing of certain cell divisions during development. LIN-14 protein levels are normally high in early development but decrease in the later stages. In a lin-4 mutant, the level of LIN-14 protein stays high throughout development, changing the pattern of cell divisions in the animal and producing defects in the shape of the animal. The lin-4 gene encodes a microRNA that binds to a sequence in the...
The dopamine transporter gene encodes a protein required to re-uptake dopamine into the pre-synaptic neuron from...
The dopamine transporter gene encodes a protein required to re-uptake dopamine into the pre-synaptic neuron from the synapse. How might a variant allele of the dopamine transporter gene, which results in a transporter protein with increased function , be involved in predisposing an individual to addictive behavior? A) The dopamine transporter variant allele would produce more dopamine in response to addictive behavior B) The dopamine transporter variant allele would produce less dopamine in response to addictive behavior C) The dopamine...
3) Proto-oncogenes can be converted to oncogenes by various genetic changes. Which of these mechanisms is...
3) Proto-oncogenes can be converted to oncogenes by various genetic changes. Which of these mechanisms is not likely to contribute to conversion to an oncogene? Select one: A: Extra copies of the gene are made, thereby enhancing expression. B: A mutation occurs upstream of the gene that results in a more active promoter. C: Chromosomes break and fragments are translocated from one chromosome to another. D: Point mutations occur that result in a protein more resistant to degradation. E: All...
Genetics Worksheet Week 3: Gene Regulation and Epigenetics 1. Duchenne muscular dystrophy is caused by a mutation in a gene that is 2.5 million nucleotides in length and encodes a protein called dyst...
Genetics Worksheet Week 3: Gene Regulation and Epigenetics 1. Duchenne muscular dystrophy is caused by a mutation in a gene that is 2.5 million nucleotides in length and encodes a protein called dystrophin. The dystrophin protein itself is 3684 amino acids in length. Calculate below the approximate size of the mRNA that encodes dystrophin. Approximately what percentage of the gene that encodes dystrophin is intron sequence? The human genome encodes a much greater variety and number of proteins than the...
You are conducting an experiment identifying enhancers that regulate the expression of a gene that codifies...
You are conducting an experiment identifying enhancers that
regulate the expression of a gene that codifies for a protein that
participates in cell division. The gene is called Mitosis
Regulatory Protein A or MRPA. The complete DNA sequences
for the MRPA promoter and coding region have been
identified. However, it is unknown if MRPA has enhancers
regulating its transcription. To answer this question your lab
first produced a transgenic cell line where GFP has been inserted
as a reporter gene....
please answer all the question to get a like. Part III Dr. Hernandez sits down with...
please answer all the question to get a like. Part III Dr. Hernandez sits down with Ann and her partner. The doctor is sorry to report that Ann has breast cancer; however, because it was caught early and responds to estrogen and progesterone, the prognosis is good. At this point it looks like the cancer is stage 1. However, as Ann is young, the doctor wants to perform a couple of tests. The first test is a genetic sequencing test...
Mutations in the exons of eukaryotic genes can result in changes in the translated protein. Nonexonic mutations, mutations in regions of a gene outside of the exons, can also alter the rate of transcription and the final protein. In which of the following situations would nonexonic mutations either affect expression of the gene or alter the structure of the final protein? Select all of the statements that apply.
please help
6. How can a missense mutation-such as in sickle cell disease-result in a protein that has an abnormal structure? Some of these mutations are lethal or cause serious disease, such as cystic fibrosis and sickle cell disease. Many of these point mutations that cause genetic disorders occur as a result of errors in DNA replication or crossing over. 7. What will be the consequence if a single base is deleted from the coding region of a gene?
For Questions 4-18, consider the mutations described in the left-hand column below. Identify whether the Lac operon will be ON or OFF in each of the environments listed across the top. The expression of the normal (wild type) operon is given. Note that "ON" and "OFF" refer to whether the operon is expressed at high levels (ON) or basal//low/no levels (OFF). (Hint: mutations render the indicated site inactive while leaving the remaining part of the operon or protein functional.) Note...
3. (2 points) In the nematode roundworm, Caenorhabditis elegans, the LIN-14 protein controls the timing of certain cell divisions during development. LIN-14 protein levels are normally high in early development but decrease in the later stages. In a lin-4 mutant, the level of LIN-14 protein stays high throughout development, changing the pattern of cell divisions in the animal and producing defects in the shape of the animal. The lin-4 gene encodes a microRNA that binds to a sequence in the...
Genetics Worksheet Week 3: Gene Regulation and Epigenetics 1. Duchenne muscular dystrophy is caused by a mutation in a gene that is 2.5 million nucleotides in length and encodes a protein called dystrophin. The dystrophin protein itself is 3684 amino acids in length. Calculate below the approximate size of the mRNA that encodes dystrophin. Approximately what percentage of the gene that encodes dystrophin is intron sequence? The human genome encodes a much greater variety and number of proteins than the...
You are conducting an experiment identifying enhancers that
regulate the expression of a gene that codifies for a protein that
participates in cell division. The gene is called Mitosis
Regulatory Protein A or MRPA. The complete DNA sequences
for the MRPA promoter and coding region have been
identified. However, it is unknown if MRPA has enhancers
regulating its transcription. To answer this question your lab
first produced a transgenic cell line where GFP has been inserted
as a reporter gene....
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