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Which of the following is true of both the androgen receptor and a retinoid receptor ?...

Which of the following is true of both the androgen receptor and a retinoid receptor ? More than one answer can be correct.

They are always located in the nucleus.

The receptors' NLS is always exposed.

They can bind steroid ligands.

They can signal at the plasma membrane.
They can undergo a conformational change upon binding of a ligand.
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Answer #1

They are always located in the nucleus

They can undergo conformational change upon binding of a ligand

The androgen receptors belong to nuclear receptor subfamily 3 and it is activated when androgenic hormones bind to it. They are translocated and present in the nucleus. The retinoid receptor bind to retinal cells and undergoes a conformational change. These receptors are located in the nucleus.  The androgen receptor is basically a DNA binding transcription factor and helps in regulating the gene expression. They bind to their ligands and hence help in development of male phenotypes

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