What effect did each drug have on cell motility?
a. Cytochalasin D
b. Cholchicine
c. Taxol
Name of drug |
Effect |
Cytochalasin D |
It is reported to belong to the class of mycotoxins. Cytochalasin D is a potential inhibitor of actin polymerization and it is permeable through the cell. It is capable of disrupting the actin microfilaments. This drug is believed to bind to F-actin polymer and averts the polymerization of actin monomers. |
Cholchicine |
Colchicine interferes with the formation of microtubules by disrupting the polymerization of β-tubulin. The drug prevents the activation, degranulation, and motility of neutrophils to places of inflammation. |
Taxol |
Taxol disturbs the microtubule dynamics and can potentially suppress the plus-end dynamics of microtubules in the viable cells. It is also reported to inhibit the compaction of microtubules eventually inactivating it. |
What effect did each drug have on cell motility? a. Cytochalasin D b. Cholchicine c. Taxol
Predict what effect taxol, colchicine and cytochalasin D will have on cilia length and the actin cytoskeleton.
You have a 100X stock of cytochalasin (a drug that depolymerizes actin). You want to treat some cells with cytochalasin and caffeine to see what happens. The cells are already in 200μl of a solution of caffeine at approximately the right concentration. How much cytochalasin would you add to the cells in caffeine?
Question 1 20 pts Cytochalasin is a drug that caps actin filament plus ends, thus preventing actin polymerization. Phalloidin is a drug that binds to and stabilizes actin filaments, preventing actin depolymerization. Even though these drugs have opposite effects on actin polymerization, the addition of either of these drugs instantaneously freezes the cell movements that depends on actin filaments. Explain why drugs that have opposite effects on actin filaments can have a similar effect on cell movements.
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