Question

ERAD, or ER associated degradation, is a quality control measure with the following function:

A.	misfolded proteins activate the expression of genes such as chaperones that will help to refold and stabilize misfolded proteins until the fold correctly

B. misfolded proteins are ubiquitinated and degraded by proteeasomes inside the ER

C.

by recognizing the structure of carbohydrates attached to proteins in the ER, incorrectly folded proteins are retained in the ER, allowing for multiple cycles of refolding, proteins that cannot fold correctly are ejected from the ER through the translocon and degraded by the ubiquitin proteasome system

D.	Unfolded proteins in ER activate a transmembrane kinase in the ER that phosphoryates misfolded proteins that are sent to the lysosome in vesicles for drgradation

Answer 1

C.

by recognizing the structure of carbohydrates attached to proteins in the ER, incorrectly folded proteins are retained in the ER, allowing for multiple cycles of refolding, proteins that cannot fold correctly are ejected from the ER through the translocon and degraded by the ubiquitin proteasome system