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Explain how a chemical that blocks the binding of EGF to the EGFR would interfere with...

Explain how a chemical that blocks the binding of EGF to the EGFR would interfere with the replication of cancerous cells that overexpress EGFR.

a) It will activate the EGFR pathway.

b) It will block the EGFR pathway.

c) It will have no effect and the EGFR pathway will continue normally

d) It will lead to overexpression of the EGFR pathway

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Answer #1

EGFR is a receptor tyrosine kinase.EGFR binds to the EGF, then the EGFR dimerizes and cross phosphorylates and phosphorylates downstream component and signal transduction happens in the cell, it activates Ras protein and finally lead to cell cycle progression, in the cancer treatment the cell cycle progression has to be prevented so the drug which binds to the EGRF should block the EGFR pathway so the answer is b) It will block the EGFR pathway.

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