Are all the amino acids in the CDR's of the BCR of a naive B cell...
Are all the amino acids in the CDR's of the BCR of a naive B cell coded for by the genome? if yes explain the mechanisms which guarentee this. if no explain how this happens and where in the V domain structure these amino acids end up.
Homework Answers
Answer :)
Yes, all amino acids are coded by the genome to make the CDR sequences of Naïve B cells. This variability of CDR occurs through three mechanisms:
P-addition: It is palindromic-sequence addition, in which new DNA segments are added at the end of the gene.
N-addition: In this addition, random nucleotides up to 15 are added in between two gene segments.
Somatic hypermutation: It happens after a B-cell encounters its definite antigen and involves a seriously increased chance of mutation in all CDRs.
Add Answer to:
Are all the amino acids in the CDR's of the BCR of a
naive B cell...
Say you have a mature, but still naive B cell. Ifone of the BCRs has a...
Say you have a mature, but still naive B cell. Ifone of the BCRs has a variable domain of the light chain encoded by V segment seventy six and J segment two, would you expect all of the BCRs to have the light chain encoded by the same segments? Further going off this information, would the variable domain of the Heavy Chain be encoded by the same V segments? Lastly, would this cell already have rearranged genetic material that codes...
Trypsin, chymotrypsin, and elastase are all serine proteases that cleave after different amino acids. What is...
Trypsin, chymotrypsin, and elastase are all serine proteases that cleave after different amino acids. What is responsible for the substrate specificity? Choose one: A. Different amino acids involved in the catalytic triad OB. Each protease is made in a different cell type. C. The substrate binding pockets accommodate different amino acids. D. Different catalytic mechanisms
Proteins • Food sources of proteins as shown in Choose My Foods booklet • Amino Acids • Structure of the amino acid...
Proteins • Food sources of proteins as shown in Choose My Foods booklet • Amino Acids • Structure of the amino acids and where each amino acids differ • #of total, essential and non-essential fatty acids needs Source of the amino acid pool and turnover of body proteins Definition of conditional (conditionally essential) amino acids • Proteins Definition of primary structure, secondary, tertiary and quaternary structure of proteins and what denaturation is Know how quality of dietary proteins are determined...
6) Proteins are composed of amino acids polymerized into long chains. The structure of a protein...
6) Proteins are composed of amino acids polymerized into long chains. The structure of a protein - that is, its overall shape and how the chains are "folded” around each other - is very important for its function. In an aqueous environment, in an active, folded state the hydrophilic amino acids in the protein are facing outwards exposed to the water and the hydrophobic amino acids are hidden away from the water in the core of the protein. In a...
All amino acids in proteins are Select one: O a. alpha-amino acid O b. (R)-amino acids...
All amino acids in proteins are Select one: O a. alpha-amino acid O b. (R)-amino acids c. acidic O d chiral
All amino acids in proteins are Select one: O a. (R)-amino acids b. chiral c. alpha-amino...
All amino acids in proteins are Select one: O a. (R)-amino acids b. chiral c. alpha-amino acid O 0 d. acidic
. Gleevec (Imatinib) inhibits protein kinase BCR-ABL, which is constitutively active in patients with Chronic Myelogenous...
. Gleevec (Imatinib) inhibits protein kinase BCR-ABL, which is
constitutively active in patients with Chronic Myelogenous Leukemia
(CML). The structure of Gleevec is shown below:
a) Based on our discussion in lecture and the structure above,
explain how the “lead” compound structure for Gleevec was designed
and how it led to the development a compound that could bind ABL
with higher affinity than ATP.
b) Using a broad kinase inhibition assay, you discover that
Gleevec inhibits another tyrosine kinase called...
a) which amino acid tested is most polar? b) look up the structure of the amino...
a) which amino acid tested is most polar?
b) look up the structure of the amino acids. explain why it
makes sense that the amino acid you listed is more polar than the
others?
c) what amino acids are in the fruit juice?
D. CHROMATOGRAPHY Chromatography is a general technique that is used to separate various materials. In this case, students can use the unique chemistry of the amino acid to determine its migration in a specific solvent. The solutions...
Please answer all.... Thank you! 81)If a polypeptide chain contains 600 amino acids, then the gene...
Please answer all.... Thank you!
81)If a polypeptide chain contains 600 amino acids, then the
gene coding for this polypeptide must contain _____.
600 nucleotides
1200 nucleotides
1800 nucleotides
1800 codons
1800 anticodons
More than one of the above are correct.
82) When we altered gene triplet in the DNA produces a chain-terminating codon in the mRNA, the (1pts) result is called a reverse mutation nonsense mutation missense mutation spontaneous mutation frameshift mutation 83) A single base substitution changes the...
Consider the following amino acids. Based off their side chains
4. Consider the following amino acids. Based off their side chains, which would you suspect to be the most prevalent in the hydrophobic core of a protein. Justify your response. 5. Are the hydrophobic interactions caused by the repulsion between water and nonpolar molecules? Explain in your own words what happens to the water structure near hydrophobic molecule? Is water special?
Trypsin, chymotrypsin, and elastase are all serine proteases that cleave after different amino acids. What is responsible for the substrate specificity? Choose one: A. Different amino acids involved in the catalytic triad OB. Each protease is made in a different cell type. C. The substrate binding pockets accommodate different amino acids. D. Different catalytic mechanisms
Proteins • Food sources of proteins as shown in Choose My Foods booklet • Amino Acids • Structure of the amino acids and where each amino acids differ • #of total, essential and non-essential fatty acids needs Source of the amino acid pool and turnover of body proteins Definition of conditional (conditionally essential) amino acids • Proteins Definition of primary structure, secondary, tertiary and quaternary structure of proteins and what denaturation is Know how quality of dietary proteins are determined...
6) Proteins are composed of amino acids polymerized into long chains. The structure of a protein - that is, its overall shape and how the chains are "folded” around each other - is very important for its function. In an aqueous environment, in an active, folded state the hydrophilic amino acids in the protein are facing outwards exposed to the water and the hydrophobic amino acids are hidden away from the water in the core of the protein. In a...
All amino acids in proteins are Select one: O a. alpha-amino acid O b. (R)-amino acids c. acidic O d chiral
All amino acids in proteins are Select one: O a. (R)-amino acids b. chiral c. alpha-amino acid O 0 d. acidic
. Gleevec (Imatinib) inhibits protein kinase BCR-ABL, which is
constitutively active in patients with Chronic Myelogenous Leukemia
(CML). The structure of Gleevec is shown below:
a) Based on our discussion in lecture and the structure above,
explain how the “lead” compound structure for Gleevec was designed
and how it led to the development a compound that could bind ABL
with higher affinity than ATP.
b) Using a broad kinase inhibition assay, you discover that
Gleevec inhibits another tyrosine kinase called...
a) which amino acid tested is most polar?
b) look up the structure of the amino acids. explain why it
makes sense that the amino acid you listed is more polar than the
others?
c) what amino acids are in the fruit juice?
D. CHROMATOGRAPHY Chromatography is a general technique that is used to separate various materials. In this case, students can use the unique chemistry of the amino acid to determine its migration in a specific solvent. The solutions...
Please answer all.... Thank you!
81)If a polypeptide chain contains 600 amino acids, then the
gene coding for this polypeptide must contain _____.
600 nucleotides
1200 nucleotides
1800 nucleotides
1800 codons
1800 anticodons
More than one of the above are correct.
82) When we altered gene triplet in the DNA produces a chain-terminating codon in the mRNA, the (1pts) result is called a reverse mutation nonsense mutation missense mutation spontaneous mutation frameshift mutation 83) A single base substitution changes the...
Most questions answered within 3 hours.
-
1. Sketch the expected Mass Spectrum of Pentane (C5H12)
2. Draw the most stable Newman projection...
asked 13 seconds ago -
There are changes in the dynamics of a relationship of a family
when family takes on...
asked 2 minutes ago -
Prove that the following is a valid cumulative distribution
function
F(x) = x/(1+x) for a>=0
0...
asked 2 minutes ago -
Caculate the PH THANK YOU!
[OH−] = 1.9×10−7 M
[OH−] = 1.6×10−8 M
[OH−] = 7.2×10−11...
asked 13 minutes ago -
Suppose you drive an old truck with a 32 gallon gas tank that
gets 16 miles/gallon....
asked 15 minutes ago -
What can be the anticipated results of curing diabetes with stem
cells?
asked 11 minutes ago -
As
an analyst you believe that Acme Company will pay a dividend of $3
per share...
asked 20 minutes ago -
Claim: At most 81% of adults do not have hypertension. When 869
randomly selected adults were...
asked 36 minutes ago -
Assume a class has 19 members.
a. In how many ways can a president, a vice...
asked 34 minutes ago -
What could be a possible reason that protozoan infections are
increasing in the United States
asked 33 minutes ago -
Implement a Full Adder with two 4x1 Mux and the MSB as possible
inputs of the...
asked 42 minutes ago -
offering the survey (maybe via smart phones) is a good idea?
why?
asked 39 minutes ago