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Identify the downstream effects of the following mutations in lambda phage. Explain how each mutation would...

Identify the downstream effects of the following mutations in lambda phage. Explain how each mutation would then favor the lysogenic or lytic cycles: A) mutation on the cIII gene. B) A mutation on PRM, C) A mutation on the N gene

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Answer #1

(A) The clll gene protects the cll protein from proteolysis by acting as competitive inhibitor. This leads to bacteriostatic state, which further favours lysogeny. Thus we can say that clll helps to stabilize the clll protein. Mutation on the clll gene will disrupt the lifestyle of lambda phage, resulting into the lytic pathway. i.e. Maintenance of lysogeny will be disturbed.

(B) PRM acts as promotor, and maintains the level of cl. It helps in producing cl protein. Thus mutation on PRM will disrupt the cl, and so the lysogenic cycle. More of transcription will result.

(C) The N gene promotes early transcription. It's mutation will pause up the transcription. Then N-antitermination complex will regulate lytic cycle.

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