Question

Protein crystallography essay: please write a detailed essay with diagrams on X-ray crystallography. Your answer must include:

(A) the typical strategy of determining a three dimensional structure of a macromolecule using X-ray crystallography.

(B) how protein crystallography is used in a drug design pipeline and discuss why protein crystallography is useful for the development of new therapeutics or the optimisation of existing pharmaceuticals

(C) the major steps involved in using X-ray crystallography for drug design

(D) The advantages and disadvantages/limitations of X-ray crystallography.

This must be a detailed long essay style answer.

Answer 1