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Predict the clinical outcome of a genetic defect in IRAK4, a protein required for the MyD88...

Predict the clinical outcome of a genetic defect in IRAK4, a protein required for the MyD88 pathway.

A. Increased rates of cancer

B. Increased rates of autoimmune disease

C. Decreased muscle tone

D. Increased rates of bacterial infection

E. Increased TLR signaling

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Answer #1

Answer -- D --- increased rates of bacterial infection.

IRAK4 is serine/therionine kinase that plays an important role in the activation of innate immune response against foreign pathogen. MyD88 protein is used in TLR signalling, TLRs are responsible for recognizing LPS in bacteria.

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