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Predict the consequences of a temperature sensitive mutation in which the phosphorylation of the β-catenin protein...

Predict the consequences of a temperature sensitive mutation in which the phosphorylation of the β-catenin protein is blocked. Above the permissive temperature:

A.

β-catenin levels will increase and β-catenin will be constitutively active.

B.

β-catenin levels will increase and β-catenin will be inactive.

C.

β-catenin levels will decrease and β-catenin will be constitutively active.

D.

β-catenin levels will decrease and β-catenin will be inactive.

E.

β-catenin levels will remain constant but cells will be unresponsive to Wnt signaling.

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Answer #1

A. Beta-catenin levels will increase and beta-catenin will be constitutively active.

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