The enzyme fructose 1,6-bisphosphatase is involved in different metabolic pathways. In anabolic pathways such as gluconeogenesis, the enzyme fructose 1, 6-bisphosphatase involves in the conversion of fructose-1, 6-bisphosphate to fructose 6-phosphate.
This enzyme is stimulated by ATP. Fructose 2, 6- phosphate stimulates phosphofructokinase and inhibits fructose 1, 6-bisphosphatase . Hence these two enzymes acts reverse to each other. Hence fructose 2, 6-phosphate also plays a role in the regulation of the enzyme fructose 1, 6-bisphosphatase.
mechanism of action of the enzyme fructose 1,6-bisphosphatase? how is the enzyme regulated
BIOCHEM Compare and contrast how fructose‐1,6‐bisphosphatase and phosphofructokinase are regulated in response to energy charge. What specific allosteric effectors are involved? What is meant by reciprocal regulation. Pyruvate kinase is also regulated allosterically by fructose‐1,6‐bisphosphate. Explain the rationale for this regulation. Do these compounds stimulate or inhibit pyruvate kinase?
A congenital defect in the liver enzyme fructose-1,6-bisphosphatase may result in metabolic acidosis. Explain.
Consider the fructose-1,6-bisphosphatase reaction... Thank you!!! Consider the fructose-1,6-bisphosphatase reaction. Calculate the free energy change if the ratio of the concentrations of the products to the concentrations of the reactants is 20.9 and the temperature is 37.0°C? AG for the reaction is -16.7 kJ/mol. AG= kJ/mol
Fructose 2,6-bisphosphate a. activates fructose 1,6-bisphosphatase. b. inhibits fructose 2,6-bisphosphatase. c. activates pyruvate kinase. d. activates phosphofructokinase. e. production is stimulated by glucagon.
what forces stabilize secondary, tertiary, and possible quaternary structure of Fructose 1,6 bisphosphatase? where is the catalytic site and what is the ionization state the side chains at the optimal pH for this enzyme?
Explain in detail how PFK-1, hexokinase, glucokinase, pyruvate kinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase-1, pyruvate carboxylase & PEPCK are regulated & compare their regulation in liver vs. skeletal muscle & brain when blood glucose levels are high (i.e. a fed state) & low (i.e. a fasting or starvation state).
Consider the fructose-1,6-bisphosphatase reaction. Calculate the free energy change if the ratio of the concentrations of the products to the concentrations of the reactants is 20.9 and the temperature is 37.0 °C? AG'for the reaction is -16.7 kJ/mol. AG= AG= kJ/mol
Which pair of opposite enzymes in the glycolysis and gluconeogenesis pathway are not allosterically regulated but rather regulated by compartmentalization? Select one: a. pyruvate kinase/PEP carboxykinase b. phosphofructokinase 1/fructose-1,6-bisphosphatase c. phosphofructokinase 2/fructose-2,6-bisphosphatase d. hexokinase/glucose-6-phosphatase
match the following 1. Fructose 1,6-bisphosphate is converted to Fructose 6- phosphate through this enzyme _____ 2. Synthesis of glucose from noncarbohydrate precursors _____ 3. Stage in which two molecules of ATP are consumed _____ 4. This is formed from pyruvate in yeast and several other microorganisms through fermentation _____ 5. The isomerization of glucose 6-phosphate to fructose 6-phosphate is a coversion of an aldose into a …._____ 6. Pyruvate is converted by pyruvate carboxylase into this intermediate _____ 7....
Question 6 2 pts Fructose 1,6-P2 aldolase functions in both glycolysis and gluconeogenesis. Starting with DHAP in Schiff base linkage with the active site lysine of aldolase, show how that intermediate reacts with G 3-P to form fructose 1,6-P2 in Schiff base linkage at the active site. Use B: and HA as necessary. Make sure that you indicate mechanism with curly arrows, and draw each step out, but don't go all the way to the end of the reaction where...