Maple syrup Urine disease (autosomal recessive) occurs in 1 in 380 live births in the old...
Maple syrup Urine disease (autosomal recessive) occurs in 1 in 380 live births in the old order Mennonite population. what is the carrier frequency of the MSUD disease allele in this population? what about in the general population, where 1 MSUD case occurs in 180,00 live births
Homework Answers
Estimation of carried frequency
In the incidence of autosomal recessive disorder like MSUD calculate carrier frequency by use of some simple algebra.
q2=1/380
=1/19
p+q=1
P= 18/19
Carrier frequency can be calculated as 2*p*q
=2*18/19*1/19=~1 in 10
In case of general population
q2=1/18000
q=1/134
p+q=1
P= 133/134
Carrier frequency can calculated as 2*p*q
=2*133/134*1/134=~1 in 67
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