Gaucher disease is an autosomal recessive disease that occurs at a frequency of 1 in 76.7,...

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Gaucher disease is an autosomal recessive disease that occurs at a frequency of 1 in 76.7,...

Gaucher disease is an autosomal recessive disease that occurs at a frequency of 1 in 76.7, or q² = 0.013. Let’s assume Gaucher disease is in mutation selection balance. Assuming a mutation rate of µ = 10^-5, calculate the selection coefficient (s) against the allele.

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Answer 1

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The question is based on Mutation selection balance. Mutation introduces mutant alleles in the population at some rate and the selection eliminates them. Further detailed explanation of the question is attached:

Solution :D mutation Selection balance : S = selection coefficient. :? u= mutation rate a los q2. 0.013 - 767 we know that mu

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Answer 2

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Gaucher disease is an autosomal recessive disease that occurs at a frequency of 1 in 76.7,...

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