Question

All of the following are true regarding B-cell development EXCEPT:

A. B cells complete maturation in the spleen.

B. B cells are mostly developed when they leave the bone marrow.

C. B cells cannot present antigens to T cells.

D. Self-reactive B cells may be eliminated though apoptosis.

E. Self- reactive B cells may be rendered unreactive (anergic).

Answer 1

QUESTION-1

ANSWER-C

All of the following are true regarding B-cell development except,

C. B cells cannot present antigens to T-cells.

EXPLANATION-

All the given options are true for B-cell development. They are generated in bone marrow and complete the maturation process in the spleen. The main function of B cells is to produce antibodies. Self-reactive B cells are eliminated through apoptosis or they rendered unreactive. B cells act as professional antigen presenting cells along with dendritic cells, macrophages and present the antigen to the helper T cell.

B cells process the antigen and present the antigen to T cell using MHC molecule.

GOOD LUCK.