Question

QUESTION 1 Immature B cells whose BCRs are strongly activated by self antigens present in the bone marrow are induced to undergo receptor editing to change the specificity of their BCRs. True False QUESTION 2 MHC genes show codominant expression patterns, meaning any cell expressing that class of MHC molecules transcribes DNA from that genetic locus on both chromosomes in the pair (maternal and paternal) simultaneously. True False

Answer 1

Q1) True

Explanation:

During B cell development, negtive selection occurs when immature B cell encounters self antigen. Negative selection has been proposed to take place either by deletion through apoptosis or by alteration of the BCR specificity by receptor editing.

Q2) True

Explanation:

All MHC molecules are codominantly expressed and the mRNA is transcribed from the gene of both the chromosome.