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True or False Cytoplasmic NADH cannot cross into the mitochondrial membrane and must use shuttle systems...

True or False

Cytoplasmic NADH cannot cross into the mitochondrial membrane and must use shuttle systems in order to pass H+ to mitochondria.

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It is true . NADH-H+ is continuously formed in the cytoplasm by glycolysis and it must be oxidized to regenerate cytoplasmic NAD+ which is important for the process of glycolysis to proceed normally.

The mitochondrial shuttles are systems used to transport reducing agents across the inner mitochondrial membrane. NADH cannot cross the membrane, but it can reduce another molecule that can cross the membrane, so that its electrons can reach the electron transport chain.

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