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Since the Krebs Cycle is a catabolic pathway, its’usefulnessis limited when a cell has sufficient ATP....

Since the Krebs Cycle is a catabolic pathway, its’usefulnessis limited when a cell has sufficient ATP. By what mechanisms (i.e. chain of events) does a surplus of ATP feedback to slow the Krebs Cycle?

can the answer be in a paragraph or less and include the mechanism please

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Answer #1

The citric acid cycle Is primarily regulated by the ATP and the NADH. The main control point of the citrate cycle is ''Isocitrate dehydrogenase' and the 'alpha - ketoglutarate dehydrogenase'.the high concentration of the ADP bind allosterically with the isocitrate dehydrogenase and increase the affinity of the enzyme for substrate. When the amount of ATP is increase and ADP is decrease then ATP inhibit the isocitrate dehydrogenase.

***ATP also inhibit the synthesis of the Citrate from the Oxaloacetate and acet -A by inhibiting the enzyme citrate synthase allosterically.

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