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Can an enzyme/pathway be important during infection but not show an effect when it is knocked...

Can an enzyme/pathway be important during infection but not show an effect when it is knocked out? Why?

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Yes, it is true that the enzyme or certain enzyme pathways are important in many infection and due to the presence of the enzyme, it catalyze the rapid recovery by fighting against the pathogenic bacteria. There are many enzymes which prevent infection like the digestive enzymes. It is found that the digestive enzymes are important for treatment of candida infection. However, when the enzyme pathway or the production of the enzyme is knocked off, without the presence of the enzyme, it is not able to defend the body and hence it is not able to reduce the time for infection. Hence, the process of recovery from an infection becomes longer when the enzymes or pathway is knocked off.

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