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How does a Natural Killer cell decide whether or not to kill a cell? And how...

How does a Natural Killer cell decide whether or not to kill a cell? And how does it kill a cell if it does decide to kill it?

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Answer #1

Natural killer cells is a part of innate immunity. Natural killer cells identifies that cells which doesn't have class MHC I molecule at surface. Natural killer cells has the ability to kill the tumour cells which losses MHC I molecules from surface. Natural killer cells destroy these cells. So, they decide to kill a cell if they don't have MHC I molecules at surface.

Natural killer cells has azurophilic granules at the surface which produces lymphotoxin that acts upon MHC I negative cells and destroy the target cells.

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