What is one reaction you predict could be used to make Ivabradine*? Give the product/starting material, the reagent(s), and the curly arrow reaction mechanism.
(No simple acid-base reactions.)
(Note that these are predicted reactions, based on the functional groups present, they do not have to be reactions of the drug actually does undergo.)
Ivabradine molecular formula C27H36N2O5
Hydrogenation can be one reaction used to make Ivabradine
starting materials can be: ethanol, water, alkyl carboxylic acid, tertiary amine
reagents: organic solvent, the reducing agent, the coupling agent
curly arrow reaction denotes the path of moving pair of electrons. It always starts with the lone pair of electrons and ends on an atom.
What is one reaction you predict could be used to make Ivabradine*? Give the product/starting mat...
НО Ho OH Bimatoprost is a medication used to treat high pressure inside the eye including glaucoma. Based on the benzene, present one reaction that you predict the compound would undergo. (simple acid-base reactions are not permitted). Give the product/starting material, the reagent(s) and the curly arrow reaction mechanism. These are predicted reactions, based on the functional group, they do not have to be reactions the drug actually undergoes, but the reaction has to be applicable to the functional group.
Q 10 - Synthesis question. Show how the starting material can be converted to the product through any of the reactions you have learned in Ochem-l and Ochem-Il. Show all the reagents you need and indicate the stereochemistry when appropriate. You do not need to show arrow pushing like in a mechanism question, only the reactions. If a chiral molecule is formed mark the chiral center with an asterisk (*) and write "racemic" below the structure. All carbon atoms in...
1.) Please help me to figure out if this is the correct product,
and if you could also give me an arrow pushing mechanism.
(Salicylic Acid + Benzylamine reacting with EDCI, Cat. DMAP and
DMF).
2.) What is the purpose of adding EDCI as a coupling
reagent?
3.) Which groups in this reaction can undergo any type of
covalent and/or non covalent interaction with any enzymes or
receptors?
4.) What are at least two other side products other than the...
Weeks 48 5: Hydrogenation of methyl oleate to give methyl stearate . Understand the reaction stoichiometry for this lab, including balanced equation. Is Pd/C consumed in the reaction? How is H2 gas generated, and is it stoichiometric or catalytic in this reaction? Be able to identify limiting reagent, calculate theoretical and percent yield. . Why is the starting material an oil, while the product is solid (if pure)? Understand the intermolecular forces involved, and how these are different for the...
2. Predict the product and draw the mechanism for the Grignard reaction shown in the video. Show all electron pairs that participate in the reaction, electron flow arrows, and intermediates. Write a paragraph describing what is happening during the mechanism. MgBr Ph H 2.NH.Cl(aq) 3. Why must this reaction be done in two steps? (In other words, what would happen in you mixed the carbonyl. Grignard reagent, and the aqueous ammonium chloride all together?) 4. In this reaction NHCI was...
1. Provide reagents that could be used to convert the starting material to the final product shown. More than one step is required. You may list the reagents in order or show each step in the synthetic sequence. 2. Indicate a plausible mechanism for the following reaction. Be sure to show bond making and bond breaking as well as all electron movement. Every arrow counts. Be precise! Don't forget to show charges where necessary. If stereochemistry is involved, please show...
1. Provide reagents that could be used to convert the starting material to the final product shown. More than one step is required. You may list the reagents in order or show each step in the synthetic sequence. 2. Indicate a plausible mechanism for the following reaction. Be sure to show bond making and bond breaking well as all electron movement. Every arrow counts. Be precisel Don't forget to show charges where necessary. If stereochemistry is involved, please show it....
4. Reaction Fill-ins! Predict the product(s) OR starting material of the following reactions. Remember Hydride shifts are possible if when a more stable carbocation can exist (depending on reaction mechanism)! Put your answers in the indicated boxes. H2SO4 (cat.), H20 а. 1.4-product 1.2-product Br Br HBr b. Br Major product Minor produt Minor product HCI C. 1,2-product 1,4-product HI он MAJOR prod Minor prod. e. Draw the FULL electron-pushing mechanism for the reaction in part a above, INCLUDING ALL resonance...
use this table to answer the following questions.
Use this table to answer the following questions in this week's exercise. Starting compounds Benzene Common reactions Nitration Toluene Sulfonation Redox reagents H2+ Pd-C, Fe+ HCl, or Sn+ HCI Zn(Hg) +HCI+, NH NH3 + 3H + KIMnO4, Na Cr 0; +H SO + H2O ZnO +1 Halogenation Friedel-Crafts alkylation Friedel-Crafts acylation NBS + hv Examples: This question is from the homework. What reaction(s)/reagent(s) do we use to prepare the prod What is...
8. In a reaction mechanism, a substance that is produced in one step, and consumed in a later step is a(n): Intermediate. Tranistion state. Catalyst. Starting material. 9. A substance that is present before and after the reaction takes place, and may increase the reaction rate by changing its mechanism is a(n): Catalyst. Intermediate. Starting material. Product. 12. An intermediate in an acid-catalyzed esterification has a partial _____ charge at its tetrahedral carbon center. positive negative 13. Water acts as...