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Consider a gene locus with two alleles: A and a. suppose that in a certain population, the frequency of allele A to be p and

lain how to test if the observed data truly follow the HWE. State the test statistics, its asymptotic distribution and how to
Consider a gene locus with two alleles: A and a. suppose that in a certain population, the frequency of allele A to be p and allele a to be 1-p. Under Hardy-Weinberg's Equilibrium (HWE), the two alleles randomly unite to form three genotypes AA, Aa and aa with probabilities [p,2p(-, a) Suppose we know a population is under HWE, from which n subjects were sampled t0 me their genotypes. The observed frequencies are (ni, n2, ns) of the three genotypes.Form likelihood and find the MLE of p. (5 points)
lain how to test if the observed data truly follow the HWE. State the test statistics, its asymptotic distribution and how to get a p-value. (5 points) b) Exp
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in t trobl lem ne haurr to solre to get maxirnuun likelihood utimate un quuestion ni h2. U-p h3 multinemial Nowue geu (i-p p 叶) tw, p us the mapįmuun tekelinsed estimate

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