Question

24. Now consider that same sequence as above except that the base marked with an asterisk (") is changed from a G to an A (see below), How does that change alter the outcome -CAUCGCUCAUGAACGCAG UUAGUCAGUAGUCCUGGACC- 3 a) That change does not alter the translation product. That change alters the translation product. That is an example of a missense mutation b) The change alters one of the translation products, This is an example of a missense mutation d) c) That change alters the translation product. That is an example of a nonsense mutation e) None of the above 25, Which of the following changes to that same sequence (also shown below) results in a silent mutation? 5-CAUCGCUCAUGAACGCAGUUAGUCAGUAGUCCUGGACC- 3 123 4 56 78 9 a) Changing the "C" labeled with the "1" (below it) to an "A". b) Changing the "G" labeled with the "2" (below it) to an "A". c) Changing the "U" labeled with the "A" (below it) to a "C" d) Changing the "A" labeled with the "5" (below it) to a "U". e) Changing the "G" labeled with an "8 (below it) to an "A" 26. A good strategy for searching for the change that would most likely result in a silent mutation (in the question above) was to first: a) Look for changes to a base that is in the 1st nucleotide position of a codon. b) Look for changes to a base that is in the 2nd nucleotide position of a codon. c) Look for changes to a base that is in the 3"d nucleotide position of a codon. d) Look for changes to bases within the stop codon. e) "Strateay?1 In this class?/ No such thing!" (Don't choose! Trying to make you smile.)

Answer 1

Ans 24. Option a is correct. Mutation doesn't alter the translation product. Because CAG and After mutation CAA , both codes for same amino acid Gln glutamine.

Ans 25. Option c is correct which leads to silent mutation. Both AGU and AGC codes for same amino acid serine.

Ans 26. Option d.. If UAG mutated to UAA, or UGA then all three are stop codon .then it is silent mutation.