How does expression of alpha and beta TCR transgenes alter thymocyte development?
How does expression of alpha and beta TCR transgenes alter thymocyte development?
Homework Answers
Answer:- expression of alpha and beta TCR ( T cell receptor)
transgenes alter thymocyte development by following
mechanism:-
- CD4- and CD8- thymocytes expressing a TCR alpha chain have
decreased
capacity to give rise to CD4+ CD8+thymocytes when compared with
wild‐type thymocytes. This incomplete CD4–CD8– to CD4+ and CD8+
maturation is mediated by the transgenic TCR alpha chain pairing
with endogenous TCR beta chain but not with endogenous TCR gamma
chain.
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