Homework Answers
Gastrointestinal drugs
1.reduction of gastric acid secretion
- H2 antihistamines: cimetidine, ranitidine
- Proton pump inhibitors: Omeprazole, Lansoprazole, Pantoprazole
- Anticholinergics: Pirenzepine, Propantheline
- Prostaglandin Analogue: Misoprostol
2.Neutralization of gastric acid
- Systemic: Sodium bicarbonate, Sodium citrate
- Nonsystemic: Magnesium hydroxide
3.Ulcer protectives
Sucralfate
4.Anti-Helicobacter pylori drugs
Metronidazole, Amoxicillin
INDICATIONS
- Peptic ulcer
- bleeding peptic ulcer
- stress ulcers
- gastroesophageal reflux disease
- Zollinger-Ellison syndrome
- Aspiration pneumonia
Adverse reactions
significant complaints are diarrhoea, headache, muscle and joint pain, dizziness, atrophic gastritis (prolonged use), skin rash.
nursing intervention
- should administer before food (reduce the absorption)
- monitor complete blood count, kidney and liver function test.
- lansoprazole reduces the absorption of drugs like digoxin, ampicillin, ketoconazole, so monitor for the effectiveness of therapy.
- If significant diarrhoea is present inform physician.
- breastfeeding is contraindicated while taking this drug.
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