Question

select the right answer:

Question : : A patient is prescribed diltiazem to manage chronic angina. the effects of the drug is a) decreased cardiac output b) increased contractility c) decreased blood pressure d) increased heart rate

Question: Simvastatin has a high probability of interacting with : :a) Erythromycin b) Ketoconazole c) carbamazepine d) all of the above

Answer 1

A patient is prescribed diltiazem to manage chronic angina. the effects of the drug is

c) decreased blood pressure

Rationale

It act on vascular smooth muscle cell and produces the effect of systemic vasodilation which reduces arterial pressure by lowering vascular resistance. Thereby it decreases the blood pressure. Hence option c is correct.

Diltiazem is a calcium channel blocker that has negative inotropy and negative chronotropic which decreases heart rate and contractility. It decreases vascular resistance and increases cardiac output. Hence option a,b,d is incorrect.

Simvastatin has a high probability of interacting with :

d) all the above.

Rationale:

Simvastatin may interact with erythromycin, ketoconazole, carbamazepine and increases the blood levels of simvastatin. It increases the risk of hepatotoxicity and rarely prone to a condition of rhabdomyolysis.