strong nucleophile weak base strong bulky base strong nucleophile strong base Promote SN2/E2 weak nucleophile weak base Promote SN1/E1 Promote SN2 Promote E2 CH Br HS NCT HO CHO CHÚCHO NaNO NaOH NOME Noe HOORS Conjugate acids have pka 16-18 Conjugate acids Recall, you make hydroxide have pka 11 or alkoxide ons from the corresponding alcohol or water and Nat CH,OH (MOH) HO CH,CH,OH (EXOH) | HC-Ć-o to CH tert-BUOK NOCH KOHBU NEOBU The structures above are all ways of...
Questions about nucleophile.. I heard that, down a column, it's good nucleophile but.. generally, strong base is strong Nu (exept for solvent issue) and 'As' (from AsH3) is more polarizable than 'P' (from PH3) thus, i think, As is to weak base(since it is stable) and P is more strong.. but it's not. why?
Are these right? If not, what needs to change?
Br weak base /weale nucleophile LOEL + enantiomer
6. Do you think it is both a strong nucleophile and a strong base? Why or why not? (2pts)
How can you tell what is a weak/strong nucleophile and
a weak/strong base to determine what mechanism you use (SN1, SN2,
E1, E2)?
3. Draw a structural formula for the major organic product(s) of each reaction and specify the mechanism by which each product is formed (SNI, SN2, El, or E2). NaOH HO CH2CH ON CH3CH OH CHON CH,OH CH,OH DMSO
Sort the molecules. Strong Base (SB)= stable or unstable good or bad Leaving group Name: Weak Base (WB) = stable or unstable good or bad leaving group Category 1 (A = large e-cloud delocalizes anion): Category 2 (R= resonance stabilized anion): Category 3 (neutral): *Circle any strong bases that are NOT good nucleophiles (why?) Weak acid (WA) (2) Strong acid (pka <O) (SA) Category 1: Category 2: Category 3: If one of these molecules are present do THIS In the...
ndyla S Chapter 7 (Snl-Sn2-E1-E2) Revie w +Problems 1°Leaving group (example): Br React with the following reagents (Strong base /strong nucleophile) B) I, NC, Na (Strong nucleophile/ weak base) C) H (NaH or Ca) tBuO/tBuOH (Strong base/non- nucleophile) D) H:0, ROH, RCO2H Weak nucleophile/ very weak base- even acidie "Solvolysis" - type reactions P 2010 2° Leaving group (example): (sometimes "hindered") Ri React with the following reagents (Strong base / strong nucleophile) B) I, NC. N (Strong nucleophile/ weak base)...
How can you tell if a reactant, like the NaOH, is a
strong/weak nucleophile or base to determine what mechanism you
use? The picture provided has the correct answers. I just don't
understand how to get to them.
3. Draw a structural formula for the major organic product(s) of each reaction and specify the mechanism by which each product is formed (SN1, S2, E, or E2). E2 NaOH Н,0 CH3CH2ONa CH3CH2OH E2 CH2ONa иис CH3OH OCH3 Br CH3OH ИИ E1...
Why does a solution of a weak base and its conjugate acid act as a better buffer than does a solution of the weak base alone
2. Give an example of a weak-link public good. Explain why this good would be inefficiently provided by a market mechanism. Are there at least two levels of market provision? If so, explain.